Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis

Autor:	E. Varela, Natalia Borruel, Milagros Gallart, María Antolín, Chaysavanh Manichanh, A. Torrejón, Francisco Guarner, F. Casellas
Rok vydání:	2013
Předmět:	Adult Male medicine.medical_specialty Cross-sectional study Population Faecalibacterium prausnitzii Gram-Positive Bacteria Real-Time Polymerase Chain Reaction Gastroenterology Pathogenesis Feces Young Adult Recurrence Internal medicine Ruminococcus medicine Humans Pharmacology (medical) Colitis Young adult education Gram-Positive Bacterial Infections education.field_of_study Hepatology biology business.industry Middle Aged medicine.disease biology.organism_classification Ulcerative colitis Pedigree Cross-Sectional Studies Immunology Colitis Ulcerative Female Calprotectin business Leukocyte L1 Antigen Complex
Zdroj:	Alimentary pharmacologytherapeutics. 38(2)
ISSN:	1365-2036
Popis:	Summary Background Although incrimination of the intestinal microbiota in the pathogenesis of IBD is widely accepted, few data are available about the role of specific bacteria. Potentially, Faecalibacterium prausnitzii, bacteria with anti-inflammatory properties, might be deficient in ulcerative colitis (UC). Aim To quantify F. prausnitzii in the faecal microbiota of UC patients in remission and determine its relationship with relapse. Methods A cross-sectional study included 116 UC patients in remission, 29 first-degree relatives and 31 healthy controls. A subset of eighteen patients, recruited during the first month of remission, underwent a 1-year follow-up. Total bacteria and F. prausnitzii were measured by quantitative Real Time PCR (qPCR, copies/g). Calprotectin was determined as inflammatory index (μg/g). Results We found that F. prausnitzii was reduced in patients (median, IQR: 1.4 × 108, 5.1 × 107–4.5 × 108) and relatives (1.7 × 108, 9.3 × 107–5.1 × 108) vs. controls (6.5 × 108, 3.7 × 108–1.6 × 109, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99f104cd29cf2a352d3a73b079aa1e8 https://pubmed.ncbi.nlm.nih.gov/23937459 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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