Neurophysiological correlates of Avolition-apathy in schizophrenia: A resting-EEG microstates study
Autor: | Giordano, Giulia M., Thomas, Koenig, Armida, Mucci, Annarita, Vignapiano, Antonella, Amodio, Giorgio Di Lorenzo, Alberto, Siracusano, Antonello, Bellomo, Mario, Altamura, Palmiero, Monteleone, Pompili, Maurizio, Silvana, Galderisi, Mario, Maj, The add-on EEG study of the Italian Network for Research on Psychoses |
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Přispěvatelé: | Giordano, Giulia Maria, Koenig, Thoma, Mucci, Armida, Vignapiano, Annarita, Amodio, Antonella, Di Lorenzo, Giorgio, Siracusano, Alberto, Bellomo, Antonello, Altamura, Mario, Monteleone, Palmiero, Pompili, Maurizio, Galderisi, Silvana, Maj, Mario |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Male
Radiology Nuclear Medicine and Imaging Anhedonia Resting-EEG Audiology Electroencephalography lcsh:RC346-429 0302 clinical medicine Nuclear Medicine and Imaging Apathy schizophrenia avolition-apathy anhedonia resting-eeg brain electrical microstates Avolition-apathy Brain electrical microstates Schizophrenia Neurology Neurology (clinical) Cognitive Neuroscience medicine.diagnostic_test Brain Cognition Regular Article Middle Aged lcsh:R858-859.7 Female Schizophrenic Psychology medicine.symptom Radiology Brain electrical microstate Adult medicine.medical_specialty Asociality Rest Cognitive neuroscience lcsh:Computer applications to medicine. Medical informatics 03 medical and health sciences Young Adult medicine Humans Settore MED/25 - Psichiatria Avolition lcsh:Neurology. Diseases of the nervous system medicine.disease 030227 psychiatry 570 Life sciences biology 030217 neurology & neurosurgery |
Zdroj: | NeuroImage: Clinical, Vol 20, Iss, Pp 627-636 (2018) Giordano, Giulia M.; König, Thomas; Mucci, Armida; Vignapiano, Annarita; Amodio, Antonella; Di Lorenzo, Giorgio; Siracusano, Alberto; Bellomo, Antonello; Altamura, Mario; Monteleone, Palmiero; Pompili, Maurizio; Galderisi, Silvana; Maj, Mario (2018). Neurophysiological correlates of Avolition-apathy in schizophrenia: A resting-EEG microstates study. NeuroImage: Clinical, 20, pp. 627-636. Elsevier 10.1016/j.nicl.2018.08.031 NeuroImage : Clinical |
ISSN: | 2213-1582 |
Popis: | Background The “Avolition-apathy” domain of the negative symptoms was found to include different symptoms by factor analytic studies on ratings derived by different scales. In particular, the relationship of anhedonia with this domain is controversial. Recently introduced negative symptom rating scales provide a better assessment of anhedonia, allowing the distinction of anticipatory and consummatory aspects, which might be related to different psychopathological dimensions. The study of associations with external validators, such as electrophysiological, brain imaging or cognitive indices, might shed further light on the status of anhedonia within the Avolition-apathy domain. Objectives We used brain electrical microstates (MSs), which represent subsecond periods of quasi-stable scalp electrical field, associated with resting-state neural networks (and thus with global patterns of functional connectivity), to test whether the component symptoms of Avolition-apathy share the same correlates. Method We analyzed multichannel resting EEGs in 142 individuals with schizophrenia (SCZ) and in 64 healthy controls (HC), recruited within the add-on EEG study of the Italian Network for Research on Psychoses. Relative time contribution, duration and occurrence of four MS classes (MS-A/-B/-C/−D) were calculated. Group differences on MS parameters (contribution and duration) and their associations with negative symptom domains (assessed using the Brief Negative Symptoms Scale) were investigated. Results SCZ, in comparison to HC, showed increased contribution and duration of MS-C. The contribution of MS-A positively correlated with Avolition-apathy, but not with Expressive deficit. Within the Avolition-apathy domain, anticipatory anhedonia, avolition and asociality, but not consummatory anhedonia, showed the same correlations with MS-A contribution. Conclusion Our findings support the existence of distinct electrophysiological correlates of Avolition-apathy with respect to Expressive deficit, and lend support to the hypothesis that only the anticipatory component of anhedonia shares the same pathophysiological underpinnings of the Avolition-apathy domain. Highlights • Microstate C contribution and duration were increased in SCZ compared to HC. • Avolition-apathy was correlated with the contribution of microstate A. • Avolition-apathy might be associated with sensory processing deficit. |
Databáze: | OpenAIRE |
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