Concise review: The challenges and opportunities of employing mesenchymal stromal cells in the treatment of acute pancreatitis
| Autor: | John E. Davies, Madelaine K. Jong, Robbie R. Goodman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Stromal cell Bioengineering Mesenchymal Stem Cell Transplantation Bioinformatics 01 natural sciences Applied Microbiology and Biotechnology 03 medical and health sciences 010608 biotechnology Small animal medicine Animals 030304 developmental biology Autoimmune pancreatitis 0303 health sciences business.industry ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS Mesenchymal stem cell Mesenchymal Stem Cells Immune modulation medicine.disease Disease Models Animal Pancreatitis Acute Disease Acute pancreatitis business Biotechnology |
| Zdroj: | Biotechnology Advances. 42:107338 |
| ISSN: | 0734-9750 |
| Popis: | To date only small animal models have been employed to assess the effect of mesenchymal stromal cell (MSC) therapy on acute pancreatitis (AP), the most common cause of hospitalization for gastrointestinal diseases worldwide. We outline the challenges inherent in the small animal models of AP. We also point to specific benefits afforded by the adoption of larger animal models. The potential for MSC therapeutics in the treatment of AP was recognized over a decade ago. With sharper focus on the form of AP and development of new MSC delivery routes in larger animals, we believe the challenge can be engaged. |
| Databáze: | OpenAIRE |
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