Ileal transposition in rats reduces energy intake, body weight, and body fat most efficaciously when ingesting a high-protein diet
| Autor: | Csaba Nyakas, André P van Beek, Edit Somogyi, Gertjan van Dijk, Thomas E. Adrian, David L. Sigalet, Henry S. Koopmans, Christiaan W Hoornenborg |
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| Přispěvatelé: | Van Dijk lab, Schoemaker lab, Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty 030309 nutrition & dietetics Endocrinology Diabetes and Metabolism medicine.medical_treatment Original Contributions Energy balance 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Weight loss Food intake Internal medicine Hypophagia medicine Animals 0303 health sciences Nutrition and Dietetics Ileal transposition PYY business.industry Insulin Weight change Body Weight digestive oral and skin physiology Dietary Fats Obesity Morbid Rats Endocrinology Energy efficiency chemistry Adipose Tissue Rats Inbred Lew Lean body mass Diet High-Protein Surgery Composition (visual arts) medicine.symptom business Energy Intake hormones hormone substitutes and hormone antagonists Neurotensin |
| Zdroj: | Obesity Surgery, 30(7), 2729-2742. SPRINGER Obesity Surgery |
| ISSN: | 0960-8923 |
| Popis: | Purpose Ileal transposition (IT) allows exploration of hindgut effects of bariatric procedures in inducing weight loss and reducing adiposity. Here we investigated the role of dietary macronutrient content on IT effects in rats. Methods Male Lewis rats consuming one of three isocaloric liquid diets enriched with fat (HF), carbohydrates (HC), or protein (HP) underwent IT or sham surgery. Body weight, energy intake, energy efficiency, body composition, and (meal-induced) changes in plasma GIP, GLP-1, PYY, neurotensin, and insulin levels were measured. Results Following IT, HC intake remained highest leading to smallest weight loss among dietary groups. IT in HF rats caused high initial weight loss and profound hypophagia, but the rats caught up later, and finally had the highest body fat content among IT rats. HP diet most efficaciously supported IT-induced reduction in body weight and adiposity, but (as opposed to other diet groups) lean mass was also reduced. Energy efficiency decreased immediately after IT irrespective of diet, but normalized later. Energy intake alone explained variation in post-operative weight change by 80%. GLP-1, neurotensin, and PYY were upregulated by IT, particularly during (0–60 min) and following 17-h post-ingestive intake, with marginal diet effects. Thirty-day post-operative cumulative energy intake was negatively correlated to 17-h post-ingestive PYY levels, explaining 47% of its variation. Conclusion Reduction in energy intake underlies IT-induced weight loss, with highest efficacy of the HP diet. PYY, GLP-1, and neurotensin levels are upregulated by IT, of which PYY may be most specifically related to reduced intake and weight loss after IT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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