A child with Philadelphia positive (Ph+)-acute leukemia with myeloid morphology: one case of stem cell origin
| Autor: | Ivone B. Otazú, Virgínia Pires, Héctor N. Seuánez, Maria Helena Ornellas, Maria Kadma Carriço, Rocio Hassan, Daniel Tabak, Ilana Zalcberg |
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| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Myeloid Polymerase Chain Reaction Immunophenotyping Myelogenous hemic and lymphatic diseases Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Cell Lineage RNA Messenger Child Acute leukemia business.industry Stem Cells Myeloid leukemia Hematology Gene rearrangement medicine.disease Transplantation Leukemia medicine.anatomical_structure Oncology Immunology Female Stem cell business Follow-Up Studies Stem Cell Transplantation |
| Zdroj: | Leukemialymphoma. 45(9) |
| ISSN: | 1042-8194 |
| Popis: | Philadelphia positive (Ph+) acute myeloid leukemia (AML) is a rare and heterogeneous condition, mainly reported in adults, associated to poor prognosis and unfavorable response to therapy. Here we report clinical and laboratory findings in an 8-year-old patient diagnosed with Ph+ acute leukemia with myeloid (FAB M4) morphology. The patient consistently expressed variable levels of m-bcr, e1a2 transcripts during a 42-month follow-up after two different stem cell transplantation protocols. An immunophenotypic switch was documented, from a mixed, myeloid-lymphoid lineage to a full lymphoid phenotype following stem cell transplants, in association with an immature B-cell gene rearrangement profile and clonal instability during clinical progression. This report indicates a stem cell origin as previously suggested for Ph+ AML. |
| Databáze: | OpenAIRE |
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