microRNA-encoded behaviour in Drosophila+
| Autor: | Claudio R. Alonso, Jimena Berni, Matthias Landgraf, Joao Picao-Osorio, Jamie Johnston |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Mutant
Article 03 medical and health sciences 0302 clinical medicine Orientation microRNA Animals Drosophila Proteins Hox gene Ultrabithorax 030304 developmental biology Regulation of gene expression Genetics Homeodomain Proteins Neurons 0303 health sciences Multidisciplinary biology Behavior Animal fungi Wild type biology.organism_classification MicroRNAs Drosophila melanogaster Gene Expression Regulation Genetic Loci Larva Mutation 030217 neurology & neurosurgery Drosophila Protein Transcription Factors |
| ISSN: | 0036-8075 |
| Popis: | The relationship between microRNA (miRNA) regulation and the specification of behavior is only beginning to be explored. We found that mutation of a single miRNA locus ( miR-iab4/iab8 ) in Drosophila larvae affects the animal’s capacity to correct its orientation if turned upside down (self-righting). One of the miRNA targets involved in this behavior is the Hox gene Ultrabithorax , whose derepression in two metameric neurons leads to self-righting defects. In vivo neural activity analysis reveals that these neurons, the self-righting node (SRN), have different activity patterns in wild type and miRNA mutants, whereas thermogenetic manipulation of SRN activity results in changes in self-righting behavior. Our work thus reveals a miRNA-encoded behavior and suggests that other miRNAs might also be involved in behavioral control in Drosophila and other species. |
| Databáze: | OpenAIRE |
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