Neurocysticercosis and pharmacoresistant epilepsy: possible role of calcified lesions in epileptogenesis
| Autor: | Henrique Carrete, Nathália Stela Visoná de Figueiredo, Marlene Mayzs Odreman, Jeana Torres Corso Duarte, Mirian Salvadori Bittar Guaranha, Marcelo Freitas Schmid, Selvin Z. Reyes-Garcia, Elza Márcia Targas Yacubian, Sandra Regina Perosa, Ricardo Silva Centeno, Maria da Graça Naffah Mazacoratti, A. C. Zetehaku |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Drug Resistant Epilepsy Neurocysticercosis Epileptogenesis Lesion 03 medical and health sciences Epilepsy 0302 clinical medicine Taenia solium medicine Humans Child business.industry Electroencephalography General Medicine Kinin medicine.disease Immunohistochemistry Magnetic Resonance Imaging Pathophysiology medicine.drug_formulation_ingredient Neurology Gliosis Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Epileptic disorders : international epilepsy journal with videotape. 22(4) |
| ISSN: | 1950-6945 |
| Popis: | Neurocysticercosis is a neglected and usually poverty-related disease of high public importance. The mechanisms by which the calcified lesions cause epilepsy are not known, but have been attributed to residual perilesional gliosis or an inflammatory process. This case shows that an inflammatory response to a calcified granuloma may be associated with the development of epilepsy. The increase in glutamate and kinin B1 (pro-epileptogenic) receptors added by reduced expression of kinin B2 (anti-epileptogenic) receptors may explain the chronic epileptogenesis associated with the lesion, corroborating the hypothesis of inflammatory mechanisms involved in the pathophysiology of epilepsy in these patients. |
| Databáze: | OpenAIRE |
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