The radioenhancement potential of Schiff base derived copper (II) compounds against lung carcinoma in vitro
| Autor: | Violetta Ayvazyan, Ani Stepanyan, Guido Hildebrandt, Elina Arakelova, Arsen Arakelyan, Vahan Tonoyan, Gohar Tsakanova, Elisabeth Schültke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Lung Neoplasms
Cancer Treatment Chemical synthesis Lung and Intrathoracic Tumors chemistry.chemical_compound 0302 clinical medicine Coordination Complexes Medicine and Health Sciences Cell Analysis 0303 health sciences Multidisciplinary Schiff base Chemical Synthesis Radiographic Image Enhancement Chemistry Bioassays and Physiological Analysis Oncology Cell Processes 030220 oncology & carcinogenesis Physical Sciences Medicine Research Article Chemical Elements Cell Viability Testing Cell Survival Science chemistry.chemical_element Research and Analysis Methods Cell Growth 03 medical and health sciences Cell Line Tumor Humans Chelation Viability assay Irradiation Schiff Bases 030304 developmental biology Cell Proliferation Cell growth Carcinoma Biology and Life Sciences Cancers and Neoplasms Cell Biology Copper In vitro chemistry Nuclear chemistry |
| Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 6, p e0253553 (2021) |
| ISSN: | 1932-6203 |
| Popis: | For the last years, copper complexes have been intensively implicated in biomedical research as components of cancer treatment. Herewith, we provide highlights of the synthesis, physical measurements, structural characterization of the newly developed Cu(II) chelates of Schiff Bases, Cu(Picolinyl-L-Tryptopahanate)2, Cu(Picolinyl-L-Tyrosinate)2, Cu(Isonicotinyl-L-Tyrosinate)2, Cu(Picolinyl-L-Phenylalaninate)2, Cu(Nicotinyl-L-Phenylalaninate)2, Cu(Isonicotinyl-L-Phenylalaninate)2, and their radioenhancement capacity at kV and MV ranges of irradiation of human lung carcinoma epithelial cells in vitro. The methods of cell growth, viability and proliferation were used. All compounds exerted very potent radioenhancer capacities in the irradiated lung carcinoma cells at both kV and MV ranges in a 100 μM concentration. At a concentration of 10 μM, only Cu(Picolinyl-L-Tyrosinate)2, Cu(Isonicotinyl-L-Tyrosinate)2, Cu(Picolinyl-L-Phenylalaninate)2 possessed radioenhancer properties at kV and MV ranges. Cu(Picolinyl-L-Tryptophanate)2 showed radioenhancer properties only at kV range. Cu(Nicotinyl-L-Phenylalaninate)2 and Cu(Isonicotinyl-L-Phenylalaninate)2 showed remarkable radioenhancer activity only at MV range. All compounds acted in dose-dependent manner at both tested energy ranges. These copper (II) compounds, in combination with 1 Gy irradiation at either 120 kV or 6 MV, are more efficient at delaying cell growth of lung cancer cells and at reducing cell viability in vitro than the irradiation administered alone. Thus, we have demonstrated that the studied copper compounds have a good potential for radioenhancement. |
| Databáze: | OpenAIRE |
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