Dietary nucleotides do not alter erythrocyte long-chain polyunsaturated fatty acids in formula-fed term infants
| Autor: | Maria Makrides, Robert A. Gibson, Joanna S. Hawkes |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Erythrocytes Clinical chemistry Population Phospholipid Gestational Age Biology Biochemistry chemistry.chemical_compound Internal medicine medicine Humans education Phospholipids chemistry.chemical_classification education.field_of_study Nucleotides Organic Chemistry Infant Newborn Infant Cell Biology Infant Formula Breast Feeding Endocrinology Term Infant Infant formula chemistry Fatty Acids Unsaturated Infant Food Breast feeding Lipidology Polyunsaturated fatty acid |
| Zdroj: | Lipids. 40:631-634 |
| ISSN: | 1558-9307 0024-4201 |
| Popis: | There have been conflicting reports regarding the effectiveness of dietary nucleotides (NT) to regulate tissue desaturases and hence stimulate accumulation of both n-6 and n-3 long-chain polyunsaturated fatty acids (LCPUFA). The aim of this study was to examine the effect of NT-supplemented cow's milk-based formula on erythrocyte phospholipid FA status in a large randomized controlled trial involving a well-nourished infant population born at term. Formula-fed infants were allocated to control formula with an innate level of NT at 10 mg/L (n = 102), or formula fortified with NT at 34 mg/L (n = 98). A parallel group of breastfed infants was included as a reference. Peripheral blood samples were collected by venipuncture at 7 mon of age and erythrocyte phospholipid FA determined by capillary GC. Erythrocyte LCPUFA levels did not differ between the NT-supplemented and control formula groups and were reduced in both groups compared with breastfed infants. We conclude that there is no induction of LCPUFA accumulation in erythrocyte phospholipids of term, formula-fed infants following 7 mon of NT supplementation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink