Mucormycosis after allogeneic haematopoietic stem cell transplantation: a French Multicentre Cohort Study (2003-2008)
| Autor: | Denis Guyotat, Catherine Cordonnier, Anne Bergeron, Mauricette Michallet, Mohty M, Patricia Ribaud, Gérard Socié, Noel-Jean Milpied, Raoul Herbrecht, Fanny Lanternier, Eric Dannaoui, Raphaël Porcher, Aliénor Xhaard, Olivier Lortholary, Louis-Jean Couderc, Claire Lacroix, Sandra Malak, Legrand F, Laurence Clement |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Antifungal Microbiology (medical) medicine.medical_specialty Antifungal Agents Adolescent medicine.drug_class Anti-Inflammatory Agents Graft vs Host Disease Kaplan-Meier Estimate Internal medicine Humans Mucormycosis Medicine Child Retrospective Studies Analysis of Variance business.industry Hematopoietic Stem Cell Transplantation Breakthrough infection Retrospective cohort study General Medicine Antibiotic Prophylaxis Middle Aged medicine.disease Allogeneic haematopoietic stem cell transplantation Surgery Transplantation Haematopoiesis Infectious Diseases Child Preschool Female France Stem cell business Cohort study |
| Zdroj: | Clinical Microbiology and Infection. 18(10):E396-E400 |
| ISSN: | 1198-743X |
| DOI: | 10.1111/j.1469-0691.2012.03908.x |
| Popis: | We conducted a nationwide retrospective study to evaluate clinical characteristics and outcome of mucormycosis among allogeneic haematopoietic stem cell transplant recipients. Twenty-nine patients were diagnosed between 2003 and 2008. Mucormycosis occurred at a median of 225 days after allogeneic haematopoietic stem cell transplant, and as a breakthrough infection in 23 cases. Twenty-six patients were receiving steroids, mainly for graft-versus-host disease treatment, while ten had experienced a prior post-transplant invasive fungal infection. Twenty-six patients received an antifungal treatment; surgery was performed in 12. Overall survival was 34% at 3 months and 17% at 1 year. |
| Databáze: | OpenAIRE |
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