Deaminative Reductive Methylation of Alkylpyridinium Salts
| Autor: | Mary P. Watson, Thomas E. Mortimer, Shane Plunkett, Olivia P. Bercher |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Molecular Structure Reductive methylation Organic Chemistry Salt (chemistry) Pyridinium Compounds Methylation Biochemistry Catalysis Article Alkyl amine Organic molecules chemistry.chemical_compound chemistry Nickel Functional group Surface modification Organic chemistry Pyridinium Amines Physical and Theoretical Chemistry Methyl iodide |
| Zdroj: | Org Lett |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Methyl groups can imbue valuable properties in organic molecules, often leading to enhanced bioactivity. To enable efficient installation of methyl groups on simple building blocks and in late-stage functionalization, a nickel-catalyzed reductive coupling of secondary Katritzky alkylpyridinium salts with methyl iodide was developed. When coupled with formation of the pyridinium salt from an alkyl amine, this method allows amino groups to be readily transformed into methyl groups with broad functional group and heterocycle tolerance. |
| Databáze: | OpenAIRE |
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