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Objective: To observe the effect of TongFengNing Decoction (TD) on uric acid levels, xanthine oxidase (XOD) activity, and XOD mRNA expression of hyperuricemia (HUA) model rats. Methods: 90 rats were randomly divided into 6 groups (n=15), and the HUA model in all groups except the blank group was established by administering hypoxanthine (HX) by gavage and injecting potassium oxonate (OAPS) intraperitoneally. Rats in all TD groups and allopurinol group were administered multiple doses of TD and a single dose of allopurinol by gavage twice daily for 21 days, while the blank group and the model group were administered normal saline. On the 7th, 14th, and 21st days of drug intervention, serum uric acid (SUA), urine uric acid (UUA), intestinal uric acid (IUA), as well as XOD activity and mRNA expression in the liver and small intestine were measured in randomly selected 5 rats of each group. Results: On the 14th and 21st days of intervention, all TD dose groups and the allopurinol group showed decreased SUA and IUA levels, increased UUA levels, as well as decreased XOD activity and mRNA expression in the liver and small intestine, compared with the model group (P < 0.05). The low- and high-dose TD group and the allopurinol group showed increased SUA and IUA levels, as well as XOD activity and mRNA expression in the liver and small intestine, and decreased UUA levels, compared with the moderate-dose TD group (P |
