The Possible Site of Anti-Asthmatic Action ofTylophora asthmaticaon Pituitary-Adrenal Axis in Albino Rats
| Autor: | S L Udupa, M N Guruswamy, A L Udupa |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Pituitary-Adrenal System Pharmaceutical Science Stimulation Biology Analytical Chemistry Steroid Hydroxyproline chemistry.chemical_compound Internal medicine Adrenal Glands Drug Discovery medicine Animals Dexamethasone Pharmacology Plants Medicinal Vitamin C Adrenal cortex Adrenal gland Cholesterol Organic Chemistry Organ Size Asthma Rats medicine.anatomical_structure Endocrinology Complementary and alternative medicine chemistry Molecular Medicine Female medicine.drug |
| Zdroj: | Planta Medica. 57:409-413 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2006-960136 |
| Popis: | The effects of the alcoholic extract, the petroleum ether fraction, and the aqueous fraction of the alcoholic extract of Tylophora asthmatica on weight of the adrenal gland and its functional activities (as evidenced by its cholesterol and vitamin C content, plasma steroid, hydroxyproline content in skin) and pituitary-adrenal axis were studied using normal, unilaterally adrenalectomised, dexamethasone-treated (steroid suppression of ACTH), and stereotaxically hypophysectomised male albino rats. The extracts showed similar actions (i.e. stimulation of adrenals as indicated by increase in weight and decrease in cholesterol and vitamin C contents). The plasma steroid level was increased but skin hydroxyproline level findings were not conclusive. T. asthmatica was found to antagonise dexamethasone/hypophysectomy-induced suppression of pituitary on activity of the adrenals. It may be concluded that T. asthmatica may act by a direct stimulation of the adrenal cortex. |
| Databáze: | OpenAIRE |
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