Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles
| Autor: | Naoyuki Matsumoto, Kana Sakai, Shunsuke Baba, Yoshiya Hashimoto, Aki Nishiura |
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| Rok vydání: | 2011 |
| Předmět: |
Calcium Phosphates
Materials science Bone Regeneration Swine Cleft Lip Lamellar bone Skull defect Biocompatible Materials chemistry.chemical_compound Bone Density Osteogenesis Animals Mixed group Bone formation Bone regeneration General Dentistry Tissue Scaffolds Skull Anatomy Phosphate Alpha-tricalcium phosphate Cleft Palate chemistry Bone Substitutes Ceramics and Composites Biophysics Swine Miniature Particle size Collagen |
| Zdroj: | Dental materials journal. 30(6) |
| ISSN: | 1881-1361 |
| Popis: | We evaluated the effects on bone formation of combining synthesized collagen model polypeptides consisting of a Pro-Hyp-Gly [poly(PHG)] sequence and alpha-tricalcium phosphate (α-TCP) particles with various median sizes (large: 580.8 μm; small: 136.2 μm; or large and small mixed: 499.3 μm) in a skull defect model in mini-pigs. Quantitative image analyses for the volume density (VD) of new bone revealed that the VD in each α-TCP group was significantly higher than that in the poly(PHG) control group, with the mixed group showing the highest VD among all the groups at 4 weeks after implantation. Histological assessments revealed that the small α-TCP particles were almost completely degraded at 8 weeks. At 12 weeks, all sizes of α-TCP particles were completely degraded and remodeling of the lamellar bone was observed. The present findings suggest that particle size may influence the success of bone formation in defects. |
| Databáze: | OpenAIRE |
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