Human Leukocyte Antigens I and II Haplotypes Associated With Human Papillomavirus 16-Positive Invasive Cervical Cancer in Mexican Women
| Autor: | Teresa Juárez-Cedillo, Alejandro García-Carrancá, Teresa Apresa-García, Mauricio Salcedo-Vargas, Dulce María Hernández-Hernández, Julio Granados-Arriola, Isabel Alvarado-Cabrero, Alejandro Mohar-Betancourt, Ricardo M. Cerda-Flores, Gilberto Vargas-Alarcón |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Uterine Cervical Neoplasms Human leukocyte antigen Biology Gene Frequency medicine Genetic predisposition Humans Genetic Predisposition to Disease Neoplasm Invasiveness Allele Mexico Cervix Allele frequency Aged Cervical cancer Human papillomavirus 16 Polymorphism Genetic Carcinoma Histocompatibility Antigens Class I Papillomavirus Infections Haplotype Histocompatibility Antigens Class II HPV infection Obstetrics and Gynecology Middle Aged medicine.disease Virology medicine.anatomical_structure Haplotypes Oncology Case-Control Studies Immunology Female |
| Zdroj: | International Journal of Gynecologic Cancer. 19:1099-1106 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1111/igc.0b013e3181a83cf4 |
| Popis: | Infection with human papillomavirus (HPV), mainly HPV type 16, is the major etiologic factor associated with cervical cancer (CC), but HPV infection alone is not sufficient for progression of precursor lesions. Host genetic susceptibility may lead to abnormal immune response resulting from virus persistence. Several studies have suggested a possible association with specific human leukocyte antigen (HLA) class I and II alleles and CC, but results are not consistent. The association of genetic HLA class I (A and B) and HLA class II (DR*B1 and DQ*B1) haplotypes with HPV16-positive CC (n = 104) and base population controls (n = 104) was evaluated in this Mexican population study. Sequence-specific primer HLA genes were determined by polymerase chain reaction (PCR)-based methods in peripheral blood cell counts (PCR sequence-specific oligonucleotides). The cervical swabs of 208 women were tested for HPV16 by Hybrid Capture II. Allele and haplotype HLA frequencies, Hardy-Weinberg tests, and a haplotype homogeneity test were estimated using the Arlequin software v. 3.01. Odds ratio (OR) was calculated to compare cases and control women. Consistent associations across other studies in women with CC and infected by HPV16 were observed for HLA-DRB1*15 (OR, 3.9; 95% CI, 1.6-10.2) and the haplotype DRB1*15 DQB1*0602 (OR, 4.1; 95% CI, 1.4-12.7) compared with control women. The HLA-A2-B44-DR4-DQ*0302, HLA-A24-B35-DR16-DQ*0301, and HLA-A2-B40-DR4-DQ*0302 haplotypes showed a positive association with CC (OR, >1), whereas HLA-A2-B39-DR4-DQ*0302, HLA-A24-B35-DR4-DQ*0302, and HLA-A68-B40-DR4-DQ*0302 showed a negative association (OR, Abbreviations:Cervical Cancer-CC, confidence interval-CI, human leukocyte antigens-HLA, human papillomavirus-HPV, odds ratio-OR, polymerase chain reaction-PCR, relative risk-RR, relative light units-RLU, ribonucleic acid-RNA, sequence-sensitive oligonucleotide-SSO |
| Databáze: | OpenAIRE |
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