2,4-Dichlorophenoxyacetic acid influx is mediated by an active transport system in Chinese hamster ovary cells
| Autor: | Jorge R. Bergesse, Héctor Balegno |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Azides
Aminoisobutyric Acids 2 4-Dichlorophenoxyacetic acid ATPase Biological Transport Active 3-O-Methylglucose CHO Cells Toxicology Ouabain S Phase chemistry.chemical_compound Cricetinae medicine Animals Enzyme Inhibitors Sodium Azide biology Herbicides Chinese hamster ovary cell Methylglucosides General Medicine Metabolism Hydrogen-Ion Concentration Kinetics Biochemistry chemistry Culture Media Conditioned Dinitrophenol biology.protein Sodium azide 2 4-Dichlorophenoxyacetic Acid Sodium-Potassium-Exchanging ATPase Dinitrophenols medicine.drug |
| Zdroj: | Toxicology Letters. 81:167-173 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/0378-4274(95)03428-5 |
| Popis: | The influx of 2,4-dichlorophenoxyacetic acid (2,4-D) into Chinese hamster ovary (CHO) cells was studied. The cells mainly took up but did not metabolize the undissociated form of the herbicide. The uptake of 2,4-D was carried out against a concentration gradient and was inhibited by sodium azide and dinitrophenol. The results presented here show that the herbicide influx was an active, energy dependent process. (Na+ + K+)ATPase does not seem to be involved because ouabain, an inhibitor of the enzyme, did not affect the 2,4-D uptake. |
| Databáze: | OpenAIRE |
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