| Autor: |
Martin C, Moran Frenkel-Pinter, Kelvin H. Smith, Victor F. Rivera-Santana, Alyssa B. Sargon, Kaitlin C. Jacobson, Aikomari Guzman-Martinez, Loren Dean Williams, Luke J. Leman, Charles L. Liotta, Martha A. Grover, Nicholas V. Hud |
| Rok vydání: |
2022 |
| Zdroj: |
JACS Au. 2(6) |
| ISSN: |
2691-3704 |
| Popis: |
The high kinetic barrier to amide bond formation has historically placed narrow constraints on its utility in reversible chemistry applications. Slow kinetics has limited the use of amides for the generation of diverse combinatorial libraries and selection of target molecules. Current strategies for peptide-based dynamic chemistries require the use of nonpolar co-solvents or catalysts or the incorporation of functional groups that facilitate dynamic chemistry between peptides. In light of these limitations, we explored the use of depsipeptides: biorelevant copolymers of amino and hydroxy acids that would circumvent the challenges associated with dynamic peptide chemistry. Here, we describe a model system of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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