Effects of substance P on cardiovascular regulation in the rabbit
| Autor: | Jean-Claude Reynaud, Jean-Jacques Puizillout, Fabienne Martini |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Agonist Quinuclidines medicine.medical_specialty Physiology medicine.drug_class Hemodynamics Blood Pressure Substance P Baroreflex Cardiovascular System Parasympathetic nervous system chemistry.chemical_compound Piperidines Heart Rate Internal medicine medicine Animals Vertebral Artery Injections Intraventricular Chemistry General Neuroscience Antagonist Electric Stimulation Autonomic nervous system Endocrinology medicine.anatomical_structure Injections Intra-Arterial Reflex Rabbits Neurology (clinical) |
| Zdroj: | Journal of the Autonomic Nervous System. 51:143-152 |
| ISSN: | 0165-1838 |
| Popis: | The effect of substance P on blood pressure and aortic reflex was investigated in rabbits. Microinjections of substance P and Sar9, Met(O2)11-SP (a selective NK1-receptor agonist) into the floor of the fourth ventricle led to a dose-dependent increase of blood pressure and a sharp enhancement of the baroreflex. These effects were abolished by pretreatment with SR 140333 (a selective NK1-receptor antagonist). Intraventricular injection of the antagonist alone significantly decreased the amplitude of the aortic reflex. After bivabotomy, the amplitude of the parasympathetic component of the baroreflex decreased dramatically and substance P injections were no longer effective. Our results demonstrate that substance P activation of NK1 receptors plays a major role in the modulation of the parasympathetic component of the baroceptor reflex. |
| Databáze: | OpenAIRE |
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