Neonatal Outcomes at Extreme Prematurity by Gestational Age Versus Birth Weight in a Contemporary Cohort
| Autor: | Anup Katheria, Akila Subramaniam, Jeff M. Szychowski, Elizabeth B. Ausbeck, Phillip H. Allman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Birth weight Gestational Age Infant Premature Diseases Umbilical cord law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Infant Mortality medicine Birth Weight Humans 030212 general & internal medicine 030219 obstetrics & reproductive medicine business.industry Obstetrics Infant Newborn Infant Obstetrics and Gynecology Gestational age medicine.anatomical_structure Infant Extremely Low Birth Weight Neonatal outcomes Infant Extremely Premature Infant Small for Gestational Age Pediatrics Perinatology and Child Health Cohort Gestation Severe morbidity business |
| Zdroj: | American Journal of Perinatology. 38:880-888 |
| ISSN: | 1098-8785 0735-1631 |
| DOI: | 10.1055/s-0040-1722606 |
| Popis: | Objective The aim of the study is to describe the rates of neonatal death and severe neonatal morbidity in a contemporary cohort, as well as to evaluate the predictive value of birth gestational age (GA) and birth weight, independently and combined, for neonatal mortality and morbidity in the same contemporary cohort. Study Design We performed a secondary analysis of an international, multicenter randomized controlled trial of delayed umbilical cord clamping versus umbilical cord milking in preterm infants born at 230/7 to 316/7 weeks of gestation. The current analysis was restricted to infants delivered Results Of 474 neonates in the original trial, 180 (38%) were included in this analysis. Overall, death occurred in 27 (15%) and severe morbidity in 139 (77%) neonates. Rates of mortality and morbidity declined with increasing GA (mortality 54% at 23 vs. 9% at 27 weeks). SGA infants (n = 25) had significantly higher mortality compared with non-SGA infants across all GAs (p Conclusion Death and severe neonatal morbidity declined with advancing GA, with higher rates of death in SGA infants. Birth GA and birth weight were both good predictors of outcomes; however, combining the two was not more predictive, even in SGA infants. Key Points |
| Databáze: | OpenAIRE |
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