Predicting first-episode psychosis patients who will never relapse over 10 years
| Autor: | Roger M. K. Ng, Christy Lm Hui, William Tl Lo, Pak C. Sham, WS Yeung, Dicky Ws Chung, Edwin Ho Ming Lee, William G. Honer, Eric Yh Chen, Simon S.Y. Lui, Wing Chung Chang, Edwin Pf Pang, Sherry Kw Chan, Peter B. Jones, Emily Sm Chen |
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| Přispěvatelé: | Hui, Christy Lm [0000-0001-6912-208X], Apollo - University of Cambridge Repository |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Psychosis Pediatrics medicine.medical_specialty long-term follow-up law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial law Memory Recurrence Risk Factors medicine Verbal fluency test Humans Applied Psychology Randomized Controlled Trials as Topic relapse Psychiatric Status Rating Scales business.industry medicine.disease 030227 psychiatry schizophrenia Psychiatry and Mental health predictors Logistic Models Psychotic Disorders Schizophrenia dup Early psychosis Clinical Global Impression Hong Kong Female Schizophrenic Psychology Verbal memory business Neurocognitive 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Psychological medicine. 49(13) |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundAlthough relapse in psychosis is common, a small proportion of patients will not relapse in the long term. We examined the proportion and predictors of patients who never relapsed in the 10 years following complete resolution of positive symptoms from their first psychotic episode.MethodPatients who previously enrolled in a 12-month randomized controlled trial on medication discontinuation and relapse following first-episode psychosis (FEP) were followed up after 10 years. Relapse of positive symptoms was operationalized as a change from a Clinical Global Impression scale positive score of ResultsOut of 178 first-episode patients, 37 (21%) never relapsed during the 10-year period. Univariate predictors (p ⩽ 0.1) of patients who never relapsed included a duration of untreated psychosis (DUP) ⩽30 days, diagnosed with non-schizophrenia spectrum disorders, having less severe negative symptoms, and performing better in logical memory immediate recall and verbal fluency tests. A multivariate logistic regression analysis further suggested that the absence of any relapsing episodes was significantly related to better short-term verbal memory, shorter DUP, and non-schizophrenia spectrum disorders.ConclusionsTreatment delay and neurocognitive function are potentially modifiable predictors of good long-term prognosis in FEP. These predictors are informative as they can be incorporated into an optimum risk prediction model in the future, which would help with clinical decision making regarding maintenance treatment in FEP. |
| Databáze: | OpenAIRE |
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