Combining ultrafast ultrasound and high-density EMG to assess local electromechanical muscle dynamics
| Autor: | Alfred C. Schouten, Winfred Mugge, Rick Waasdorp, Jurriaan H. de Groot, Martin D. Verweij, Hendrik J. Vos, Verya Daeichin, Nico de Jong |
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| Přispěvatelé: | Biomechanical Engineering, Cardiology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Materials science General Computer Science latency relaxation Transducers multisegmental modeling Electromyography Sports biomechanics Sarcomere Biceps Hill model 03 medical and health sciences high-density electromyography 0302 clinical medicine Ultrafast ultrasound medicine General Materials Science muscle modeling Muscular dystrophy Force medicine.diagnostic_test business.industry Ultrasonic imaging Muscles Dynamics (mechanics) Ultrasound General Engineering electrostimulation excitation-contraction coupling medicine.disease 030104 developmental biology Couplings wave tracking lcsh:Electrical engineering. Electronics. Nuclear engineering Action potentials speckle-tracking Mechanical wave business lcsh:TK1-9971 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | IEEE Access, 9 IEEE Access, 9, 45277-45288. IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC IEEE Access, 9:9381253, 45277-45288. IEEE IEEE Access, Vol 9, Pp 45277-45288 (2021) IEEE Access, 9:9381253, 45277-45288. Institute of Electrical and Electronics Engineers Inc. |
| ISSN: | 2169-3536 |
| Popis: | Skeletal muscles generate force, enabling movement through a series of fast electro-mechanical activations coordinated by the central nervous system. Understanding the underlying mechanism of such fast muscle dynamics is essential in neuromuscular diagnostics, rehabilitation medicine and sports biomechanics. The unique combination of electromyography (EMG) and ultrafast ultrasound imaging (UUI) provides valuable insights into both electrical and mechanical activity of muscle fibers simultaneously, the excitation-contraction (E-C) coupling. In this feasibility study we propose a novel non-invasive method to simultaneously track the propagation of both electrical and mechanical waves in muscles using high-density electromyography and ultrafast ultrasound imaging (5000 fps). Mechanical waves were extracted from the data through an axial tissue velocity estimator based on one-lag autocorrelation. The E-C coupling in electrically evoked twitch contractions of the Biceps Brachii in healthy participants could successfully be tracked. The excitation wave (i.e. action potential) had a velocity of 3.9±0.5ms−1 and the subsequent mechanical (i.e. contraction) wave had a velocity of 3.5±0.9ms−1. The experiment showed evidence that contracting sarcomeres that were already activated by the action potential (AP) pull on sarcomeres that were not yet reached by the AP, which was corroborated by simulated contractions of a newly developed multisegmental muscle fiber model, consisting of 500 sarcomeres in series. In conclusion, our method can track the electromechanical muscle dynamics with high spatio-temporal resolution. Ultimately, characterizing E-C coupling in patients with neuromuscular diseases (e.g. Duchenne or Becker muscular dystrophy) may assess contraction efficiency, monitor the progression of the disease, and determine the efficacy of new treatment options. |
| Databáze: | OpenAIRE |
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