Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat
| Autor: | Wolfgang Schreibmayer, Christine Karschin, Norman Davidson, Henry A. Lester, Andreas Karschin, Nathan Dascal |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Potassium Channels G protein Central nervous system Biophysics In situ hybridization Granular layer Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Structural Biology GTP-Binding Proteins Internal medicine Genetics medicine Animals RNA Messenger Potassium Channels Inwardly Rectifying Rats Wistar Molecular Biology In Situ Hybridization 030304 developmental biology 0303 health sciences Inward-rectifier potassium ion channel Dentate gyrus Brain Membrane Proteins Cell Biology Potassium channel Olfactory bulb Cell biology Rats medicine.anatomical_structure Endocrinology nervous system G Protein-Coupled Inwardly-Rectifying Potassium Channels Female 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | FEBS letters. 348(2) |
| ISSN: | 0014-5793 |
| Popis: | The cellular distribution of the mRNA of the inwardly rectifying K+ channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein-activated K+ channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II–VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons support its important role as a major target channel for G protein mediated receptor function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text