Hospital-acquired serum phosphate derangements and their associated in-hospital mortality
| Autor: | Charat Thongprayoon, Fawad Qureshi, Michael A Mao, Narat Srivali, Tarun Bathini, Kianoush Kashani, Tananchai Petnak, Api Chewcharat, Saraschandra Vallabhajosyula, Wisit Cheungpasitporn |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Hypophosphatemia 030232 urology & nephrology Logistic regression Phosphates 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Hospital Mortality 030212 general & internal medicine Aged Retrospective Studies Polycomb Repressive Complex 1 Inpatients In hospital mortality Proto-Oncogene Protein c-fli-1 business.industry Incidence Incidence (epidemiology) Mortality rate General Medicine Odds ratio Serum phosphate Middle Aged Hyperphosphatemia Normal serum phosphate Female business |
| Zdroj: | Postgraduate Medical Journal. 98:43-47 |
| ISSN: | 1469-0756 0032-5473 |
| Popis: | Background We aimed to report the incidence of hospital-acquired hypophosphataemia and hyperphosphataemia along with their associated in-hospital mortality. Methods We included 15 869 adult patients hospitalised at a tertiary medical referral centre from January 2009 to December 2013, who had normal serum phosphate levels at admission and at least two serum phosphate measurements during their hospitalisation. The normal range of serum phosphate was defined as 2.5–4.2 mg/dL. In-hospital serum phosphate levels were categorised based on the occurrence of hospital-acquired hypophosphataemia and hyperphosphataemia. We analysed the association of hospital-acquired hypophosphataemia and hyperphosphataemia with in-hospital mortality using multivariable logistic regression. Results Fifty-three per cent (n=8464) of the patients developed new serum phosphate derangements during their hospitalisation. The incidence of hospital-acquired hypophosphataemia and hyperphosphataemia was 35% and 27%, respectively. Hospital-acquired hypophosphataemia and hyperphosphataemia were associated with odds ratio (OR) of 1.56 and 2.60 for in-hospital mortality, respectively (p value Conclusion Hospital-acquired serum phosphate derangements affect approximately half of the hospitalised patients and are associated with increased in-hospital mortality rate. |
| Databáze: | OpenAIRE |
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