HSV as a vector in vaccine development and gene therapy
| Autor: | Marconi, Peggy Carla Raffaella, Argnani, Rafaela, Berto, Elena, Epstein, Al, Manservigi, Roberto |
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| Přispěvatelé: | Laviron, Nathalie |
| Rok vydání: | 2008 |
| Předmět: |
viral vaccine
Genetic enhancement Genetic Vectors Immunology cancer gene therapy Herpesvirus 1 Human HSL and HSV Biology Virus Replication medicine.disease_cause Neoplasms Drug Discovery medicine Animals Simplexvirus Humans HSV-1 vectors Vector (molecular biology) General Pharmacology Toxicology and Pharmaceutics Antigens Viral [SDV.BC] Life Sciences [q-bio]/Cellular Biology Vaccines Models Genetic Vaccination nervous system Viral Vaccines Genetic Therapy Amplicon Virology Human genetics Oncolytic virus Herpes simplex virus Lytic cycle DNA Viral Genetic Engineering |
| Zdroj: | Human Vaccines. 4:91-105 |
| ISSN: | 1554-8619 1554-8600 |
| DOI: | 10.4161/hv.4.2.6212 |
| Popis: | The very deep knowledge acquired on the genetics and molecular biology of herpes simplex virus (HSV), major human pathogen whose lifestyle is based on a long-term dual interaction with the infected host characterized by the existence of lytic and latent infections, has allowed the development of potential vectors for several applications in human healthcare. These include delivery and expression of human genes to cells of the nervous system, selective destruction of cancer cells, prophylaxis against infection with HSV or other infectious diseases and targeted infection of specific tissues or organs. Three different classes of vectors can be derived from HSV-1: replication-competent attenuated vectors, replication-incompetent recombinant vectors and defective helper-dependent vectors known as amplicons. This chapter highlights the current knowledge concerning design, construction and recent applications, as well as the potential and current limitations of the three different classes of HSV-1-based vectors. |
| Databáze: | OpenAIRE |
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