Food and protein intake, glucagon, and distribution of alpha-aminoisobutyrate in the rat
| Autor: | J. K. Tews, A. E. Harper |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Low protein Aminoisobutyric Acids Time Factors Physiology Endocrinology Diabetes and Metabolism Biology Glucagon Physiology (medical) Internal medicine Casein medicine Distribution (pharmacology) Animals Tissue Distribution Kidney Tissue water Muscles Myocardium Brain Feeding Behavior Protein intake Rats medicine.anatomical_structure Endocrinology Liver Alpha aminoisobutyrate Dietary Proteins |
| Zdroj: | The American journal of physiology. 238(4) |
| ISSN: | 0002-9513 |
| Popis: | Distribution of alpha-aminoisobutyric acid (AIB) in the rat was modified by food, dietary protein, and glucagon. In rats last fed 24 h before AIB injection, AIB clearance from plasma and uptake into liver were greater in rats fed a high-protein diet (60% casein) than in rats fed the control diet (18% casein); AIB clearance from plasma and uptake into muscle were lowered by a low-protein diet (6% casein). Feeding rats lowered clearance of AIB from plasma in low- and high-protein groups. Distribution ratios (AIB concentration in tissue water/AIB in plasma) were low in all tissues but liver during the first 7 h after feeding high protein when compared to the control values; ratios were low in muscle, heart, and kidney after feeding low protein. Maximum ratios occurred at different times for different tissues; the time was delayed by the high-protein diet in all tissues but liver. Glucagon increased all ratios in rats fed the control or low-protein diets, with the smallest changes occurring in liver and muscle from low-protein rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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