Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse
| Autor: | Sònia Darbra, Marc Pallarès, Anna Llidó, Iris Bartolomé |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neuroactive steroid Physiology Alcohol abuse medicine.medical_treatment Neurodevelopment Nucleus accumbens Allopregnanolone Biochemistry lcsh:RC346-429 lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology Dopamine Internal medicine medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Molecular Biology lcsh:Neurology. Diseases of the nervous system Neuropsychiatric disorders vulnerability Endocrine and Autonomic Systems business.industry lcsh:QP351-495 Dopaminergic Ventral striatum medicine.disease 030227 psychiatry Stimulant lcsh:Neurophysiology and neuropsychology medicine.anatomical_structure chemistry Articles from the Special Issue on Allopregnanolone role in the neurobiology of stress and mood disorders Edited by Graziano Pinna business Emotional behavior Neurosteroids 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurobiology of Stress Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Neurobiology of Stress, Vol 12, Iss, Pp-(2020) |
| ISSN: | 2352-2895 |
| DOI: | 10.1016/j.ynstr.2019.100208 |
| Popis: | Several studies have highlighted the role that early postnatal levels of allopregnanolone play in the development of the CNS and adult behavior. Changes in allopregnanolone levels related to stress have been observed during early postnatal periods, and perinatal stress has been linked to neuropsychiatric disorders. The alteration of early postnatal allopregnanolone levels in the first weeks of life has been proven to affect adult behaviors, such as anxiety-related behaviors and the processing of sensory inputs. This review focuses on the first studies about the possible relationship between the early postnatal allopregnanolone levels and the vulnerability to abuse of drugs such as alcohol in adulthood, given that (1) changes in neonatal allopregnanolone levels affect novelty exploration and novelty seeking has been linked to vulnerability to drug abuse; (2) early postnatal administration of progesterone, the main allopregnanolone precursor, affects the maturation of dopaminergic meso-striatal systems, which have been related to novelty seeking and drug abuse; and (3) alcohol consumption increases plasma and brain allopregnanolone levels in animals and humans. Manipulating neonatal allopregnanolone by administering finasteride, an inhibitor of the 5α-reductase enzyme that participates in allopregnanolone synthesis, increases alcohol consumption and decreases the locomotor stimulant effects of low alcohol doses. At a molecular level, finasteride decreases dopamine and serotonin in ventral striatum and dopamine release in nucleus accumbens. Preliminary results suggest that serotonin 5HT3 receptors could also be affected. Although an in-depth study is necessary, evidence suggests that there is a relation between early postnatal allopregnanolone and vulnerability to drug use/abuse. Highlights • Early postnatal AlloP levels alteration affects brain maturation and adult behavior. • Early stress interacts to AlloP influencing neuropsychiatric disorders vulnerability. • Fluctuations in neonatal AlloP levels play a role in alcohol abuse vulnerability. • Neonatal finasteride induces novelty-seeking profile and increases ethanol intake. |
| Databáze: | OpenAIRE |
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