Development of a recombinant epsilon toxoid vaccine against enterotoxemia and its use as a combination vaccine with live attenuated sheep pox virus against enterotoxemia and sheep pox
| Autor: | Deepika Dayal Mathur, Parthasarathy Sugumar, Dev Chandran, Shahana Pallichera Vijayan, Sureddi Satyam Naidu, Gudavalli Sudha Rani, Villuppanoor Alwar Srinivasan, Lalit C. Garg |
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| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
viruses Clinical Biochemistry Immunology Bacterial Toxins Sheep Diseases Poxviridae Infections Biology Vaccines Attenuated Capripoxvirus Microbiology Enterotoxemia Immunity Formaldehyde Immunology and Allergy Potency Animals Vaccines Combined Vaccines Synthetic Sheep Viral Vaccine Toxoid virus diseases Viral Vaccines Toxoids biology.organism_classification Vaccine Research Virology Vaccination Bacterial vaccine Bacterial Vaccines |
| Zdroj: | Clinical and vaccine immunology : CVI. 17(6) |
| ISSN: | 1556-679X |
| Popis: | Sheep pox and enterotoxemia are important diseases of sheep, and these diseases cause severe economic losses to sheep farmers. The present study was undertaken to evaluate the potential of formaldehyde-inactivated recombinant epsilon toxin as a vaccine candidate. The potency of the recombinant epsilon toxoid with aluminum hydroxide as an adjuvant in sheep was determined. Vaccinated sheep were protected against enterotoxemia, with potency values of >5 IU being protective. Further, the use of this construct in a combination vaccine against sheep pox resulted in the sheep being protected against both sheep pox and enterotoxemia. |
| Databáze: | OpenAIRE |
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