Resorbable Nanocomposites with Bone-Like Strength and Enhanced Cellular Activity
| Autor: | Sichang Lu, Scott A. Guelcher, Joseph C. Wenke, B. R. Rogers, Madison A.P. McGough, Daniel A. Shimko |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Biomedical Engineering 02 engineering and technology Bone healing 010402 general chemistry 01 natural sciences Mineralization (biology) Article chemistry.chemical_compound Osteoclast medicine General Materials Science Composite material Nanocomposite General Chemistry General Medicine 021001 nanoscience & nanotechnology Bone cement Nanocrystalline material In vitro 0104 chemical sciences medicine.anatomical_structure chemistry 0210 nano-technology Caprolactone Biomedical engineering |
| Popis: | Bone cements for treatment of fractures at weight-bearing sites are subjected to dynamic physiological loading from daily activities. An ideal bone cement rapidly sets after injection, exhibits bone-like strength, stimulates osteogenic differentiation of endogenous cells, and resorbs at a rate aligned with patient biology. However, currently available materials fall short of these targeted properties. Nanocrystalline hydroxyapatite (nHA) enhances osteogenic differentiation, new bone formation, and osteoclast differentiation activity compared to amorphous or micron-scale crystalline hydroxyapatite. However, the brittle mechanical properties of nHA precludes its use in treatment of weight-bearing bone defects. In this study, we report settable nHA–poly(ester urethane) (PEUR) nanocomposites synthesized from nHA, lysine triisocyanate (LTI), and poly(caprolactone) triol via a solvent-free process. The nanocomposites are easily mixed and injected using a double-barrel syringe, exhibit mechanical properties exceeding those of conventional bone cements, enhance mineralization of osteoprogenitor cells in vitro, and undergo osteoclast-mediated degradation in vitro. This combination of properties cannot be achieved using other technologies, which underscores the potential of nHA–PEUR nanocomposites as a new approach for promoting bone healing at weight-bearing sites. |
| Databáze: | OpenAIRE |
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