Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: Relationship to glucose disposal
| Autor: | Odile Mathieu-Costello, Yan Ju, Alice Kong, Li Cui, Theodore P. Ciaraldi, Neelima Chu, Sunder Mudaliar, Dennis Kim, Robert R. Henry |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Vastus lateralis muscle medicine.drug_class Biopsy Endocrinology Diabetes and Metabolism medicine.medical_treatment Muscle Fibers Skeletal Troglitazone Endocrinology Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Chromans Thiazolidinedione Muscle Skeletal Aged Histocytochemistry Biguanide business.industry Insulin Skeletal muscle Middle Aged Lipid Metabolism medicine.disease Metformin Capillaries Microscopy Electron Thiazoles Glucose medicine.anatomical_structure Diabetes Mellitus Type 2 Regional Blood Flow Female Thiazolidinediones business medicine.drug |
| Zdroj: | Metabolism. 52:540-546 |
| ISSN: | 0026-0495 |
| DOI: | 10.1053/meta.2002.50108 |
| Popis: | The goal of this work was to compare the effects of different antidiabetic therapies on the phenotype of skeletal muscle in type 2 diabetic subjects failing sulfonylurea therapy. Subjects were treated with a thiazolidinedione (troglitazone, TGZ) or a biguanide (metformin, MET) in addition to glyburide for 3 to 4 months. Insulin action was determined with a hyperinsulinemic (300 mU. m(-2). min(-1)) euglycemic (5.0 to 5.5 mmol/L) clamp. Biopsies were obtained from the vastus lateralis muscle for morphological analysis. Despite similar glycemic control, relative increases in the insulin-stimulated glucose disposal rate (GDR) were greater after TGZ treatment (37 +/- 8% increase, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect