Renal Complications of Intravesical Bacillus Calmette-Guérin Therapy
| Autor: | J.-M. Suc, A. Modesto, L. Marty, D. Kleinknecht, J.-F. De Fremont, T. Marsepoil, P. Veyssier |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Urology urologic and male genital diseases Glomerulonephritis medicine Humans Aged Carcinoma Transitional Cell Granuloma Urinary bladder Bladder cancer Papilloma medicine.diagnostic_test business.industry Liver Diseases Immunotherapy Middle Aged medicine.disease Administration Intravesical medicine.anatomical_structure Urinary Bladder Neoplasms Nephrology Toxicity BCG Vaccine Granulomatous Hepatitis Nephritis Interstitial Kidney Diseases Renal biopsy business Nephritis |
| Zdroj: | American Journal of Nephrology. 11:501-504 |
| ISSN: | 1421-9670 0250-8095 |
| Popis: | We report 3 patients who developed signs of systemic infection and renal insufficiency after intravesical bacillus Calmette-Guérin (BCG) instillations for a bladder cancer. Renal biopsy showed tubulo-interstitial nephritis with or without epithelioid granulomas in 2 cases, and mesangial glomerulonephritis in the last case. All patients had granulomatous hepatitis in association. It seems that hematogenous dissemination via a traumatic instillation of BCG and/or an immune-complex mechanism may have contributed to the renal damage, which was only partially reversible in 2 patients. |
| Databáze: | OpenAIRE |
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