Differential effects of calcium- and vitamin D-fortified milk with FOS-inulin compared to regular milk, on bone biomarkers in Chinese pre- and postmenopausal women
| Autor: | Lee Ting Lau, Yit Siew Chin, ChinChin Lau, Barbara Kuhn-Sherlock, Yoke Mun Chan, Linda M. Schollum, Marlena C. Kruger, Joanne M. Todd |
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| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
0301 basic medicine Bone density Medicine (miscellaneous) Parathyroid hormone Body Mass Index Bone remodeling chemistry.chemical_compound 0302 clinical medicine Bone Density Surveys and Questionnaires Insulin Magnesium Vitamin D Nutrition and Dietetics Inulin Phosphorus Middle Aged Postmenopause Milk Parathyroid Hormone Food Fortified Female Waist Circumference Adult Vitamin medicine.medical_specialty chemistry.chemical_element 030209 endocrinology & metabolism Calcium Bone and Bones Collagen Type I Bone resorption 03 medical and health sciences Internal medicine medicine Vitamin D and neurology Animals Humans Bone Resorption business.industry Body Weight Dietary Fats Calcium Dietary 030104 developmental biology Endocrinology chemistry business Biomarkers Follow-Up Studies |
| Zdroj: | European Journal of Nutrition. 55:1911-1921 |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-015-1007-x |
| Popis: | To compare the effects of a high-calcium vitamin D-fortified milk with added FOS-inulin versus regular milk on serum parathyroid hormone, and bone turnover markers in premenopausal (Pre-M) and postmenopausal (PM) women over 12 weeks. Premenopausal women (n = 136, mean age 41 (±5) years) and postmenopausal women [n = 121, mean age 59 (±4) years] were recruited, and each age group randomised into two groups to take two glasses per day of control = regular milk (500 mg calcium per day) or intervention (Int) = fortified milk (1000 mg calcium for pre-M women and 1200 mg calcium for PM women, 96 mg magnesium, 2.4 mg zinc, 15 µg vitamin D, 4 g FOS-inulin per day). At baseline, week 4 and week 12 serum minerals and bone biochemical markers were measured and bone density was measured at baseline. Mean 25-hydroxyvitamin D [25(OH) vitamin D3] levels among groups were between 49 and 65 nmol/L at baseline, and over the 12 weeks of supplementation, the fortified milk improved vitamin D status in both Int groups. CTx-1 and PINP reduced significantly in both Pre-M and PM groups over the 12 weeks, with the changes in CTx-1 being significantly different (P |
| Databáze: | OpenAIRE |
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