Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study

Autor: Vanessa P. M. van Empel, Joline W.J. Beulens, Zhenyu Zhang, Lutgarde Thijs, Sharon Remmelzwaal, Petra J. M. Elders, A. Johanne van Ballegooijen, Stephane Heymans, Yolande Appelman, Coen D.A. Stehouwer, Jan A. Staessen, M. Louis Handoko
Přispěvatelé: Epidemiology and Data Science, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases, General practice, Cardiology, APH - Personalized Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, ACS - Pulmonary hypertension & thrombosis, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), Interne Geneeskunde, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Ventricular Ejection Fraction
Physiology
NSAIDs
030204 cardiovascular system & hematology
Cardiovascular Medicine
Biochemistry
Ventricular Function
Left
VENTRICULAR EJECTION FRACTION
Low grade inflammation
Cohort Studies
0302 clinical medicine
Medical Conditions
Glucose Metabolism
Left atrial
Immune Physiology
Medicine and Health Sciences
030212 general & internal medicine
Prospective Studies
Endothelial dysfunction
Immune Response
Innate Immune System
Analgesics
Sex Characteristics
Multidisciplinary
Ejection fraction
Confounding
Drugs
DIASTOLIC DYSFUNCTION
ASSOCIATION
C-Reactive Proteins
CHRONIC HEART-FAILURE
EUROPEAN-SOCIETY
PREVALENCE
Multidisciplinary Sciences
Cardiovascular Diseases
Echocardiography
Cardiology
Medicine
Biomarker (medicine)
Cytokines
Carbohydrate Metabolism
Science & Technology - Other Topics
Female
E-Selectin
Research Article
medicine.medical_specialty
Science
Immunology
Diastole
DIAGNOSIS
03 medical and health sciences
Signs and Symptoms
Internal medicine
medicine
Humans
Aged
Inflammation
Heart Failure
Pharmacology
Science & Technology
business.industry
Tumor Necrosis Factor-alpha
Biology and Life Sciences
Proteins
Stroke Volume
ADULTS
Molecular Development
medicine.disease
Pain management
Metabolism
Immune System
REACTIVE PROTEIN
Endothelium
Vascular
Clinical Medicine
business
Biomarkers
Developmental Biology
TASK-FORCE
Zdroj: PLoS ONE
PLoS ONE, 16(5 May):e0251148. Public Library of Science
PLoS ONE, Vol 16, Iss 5, p e0251148 (2021)
PLOS ONE, 16(5):0251148. Public Library of Science
Remmelzwaal, S, Beulens, J W J, Elders, P J M, Stehouwer, C D A, Zhang, Z, Handoko, M L, Appelman, Y, van Empel, V, Heymans, S R B, Thijs, L, Staessen, J A & van Ballegooijen, A J 2021, ' Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study ', PLoS ONE, vol. 16, no. 5 May, e0251148 . https://doi.org/10.1371/journal.pone.0251148
ISSN: 1932-6203
Popis: Background This study aimed to determine the within-person and between-persons associations of low-grade inflammation (LGI) and endothelial dysfunction (ED) with echocardiographic measures related to diastolic dysfunction (DD) in two general populations and whether these associations differed by sex. Methods Biomarkers and echocardiographic measures were measured at both baseline and follow-up in the Hoorn Study (n = 383) and FLEMENGHO (n = 491). Individual biomarker levels were combined into either a Z-score of LGI (CRP, SAA, IL-6, IL-8, TNF-α and sICAM-1) or ED (sICAM-1, sVCAM-1, sE-selectin and sTM). Mixed models were used to determine within-person and between-persons associations of biomarker Z-scores with left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) and left atrial volume index (LAVI). These associations were adjusted for a-priori selected confounders. Results Overall Z-scores for LGI or ED were not associated with echocardiographic measures. Effect modification by sex was apparent for ED with LVEF in both cohorts (P-for interaction = 0.08 and 0.06), but stratified results were not consistent. Effect modification by sex was apparent for TNF-α in the Hoorn Study and E-selectin in FLEMENGHO with LVEF (P-for interaction≤0.05). In the Hoorn Study, women whose TNF-α levels increased with 1-SD over time had a decrease in LVEF of 2.2 (-4.5;0.01) %. In FLEMENGHO, men whose E-selectin levels increased with 1-SD over time had a decrease in LVEF of 1.6 (-2.7;-0.5) %. Conclusion Our study did not show consistent associations of LGI and ED with echocardiographic measures. Some evidence of effect modification by sex was present for ED and specific biomarkers.
Databáze: OpenAIRE
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