Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study
Autor: | Vanessa P. M. van Empel, Joline W.J. Beulens, Zhenyu Zhang, Lutgarde Thijs, Sharon Remmelzwaal, Petra J. M. Elders, A. Johanne van Ballegooijen, Stephane Heymans, Yolande Appelman, Coen D.A. Stehouwer, Jan A. Staessen, M. Louis Handoko |
---|---|
Přispěvatelé: | Epidemiology and Data Science, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases, General practice, Cardiology, APH - Personalized Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, ACS - Pulmonary hypertension & thrombosis, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), Interne Geneeskunde, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Ventricular Ejection Fraction Physiology NSAIDs 030204 cardiovascular system & hematology Cardiovascular Medicine Biochemistry Ventricular Function Left VENTRICULAR EJECTION FRACTION Low grade inflammation Cohort Studies 0302 clinical medicine Medical Conditions Glucose Metabolism Left atrial Immune Physiology Medicine and Health Sciences 030212 general & internal medicine Prospective Studies Endothelial dysfunction Immune Response Innate Immune System Analgesics Sex Characteristics Multidisciplinary Ejection fraction Confounding Drugs DIASTOLIC DYSFUNCTION ASSOCIATION C-Reactive Proteins CHRONIC HEART-FAILURE EUROPEAN-SOCIETY PREVALENCE Multidisciplinary Sciences Cardiovascular Diseases Echocardiography Cardiology Medicine Biomarker (medicine) Cytokines Carbohydrate Metabolism Science & Technology - Other Topics Female E-Selectin Research Article medicine.medical_specialty Science Immunology Diastole DIAGNOSIS 03 medical and health sciences Signs and Symptoms Internal medicine medicine Humans Aged Inflammation Heart Failure Pharmacology Science & Technology business.industry Tumor Necrosis Factor-alpha Biology and Life Sciences Proteins Stroke Volume ADULTS Molecular Development medicine.disease Pain management Metabolism Immune System REACTIVE PROTEIN Endothelium Vascular Clinical Medicine business Biomarkers Developmental Biology TASK-FORCE |
Zdroj: | PLoS ONE PLoS ONE, 16(5 May):e0251148. Public Library of Science PLoS ONE, Vol 16, Iss 5, p e0251148 (2021) PLOS ONE, 16(5):0251148. Public Library of Science Remmelzwaal, S, Beulens, J W J, Elders, P J M, Stehouwer, C D A, Zhang, Z, Handoko, M L, Appelman, Y, van Empel, V, Heymans, S R B, Thijs, L, Staessen, J A & van Ballegooijen, A J 2021, ' Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study ', PLoS ONE, vol. 16, no. 5 May, e0251148 . https://doi.org/10.1371/journal.pone.0251148 |
ISSN: | 1932-6203 |
Popis: | Background This study aimed to determine the within-person and between-persons associations of low-grade inflammation (LGI) and endothelial dysfunction (ED) with echocardiographic measures related to diastolic dysfunction (DD) in two general populations and whether these associations differed by sex. Methods Biomarkers and echocardiographic measures were measured at both baseline and follow-up in the Hoorn Study (n = 383) and FLEMENGHO (n = 491). Individual biomarker levels were combined into either a Z-score of LGI (CRP, SAA, IL-6, IL-8, TNF-α and sICAM-1) or ED (sICAM-1, sVCAM-1, sE-selectin and sTM). Mixed models were used to determine within-person and between-persons associations of biomarker Z-scores with left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) and left atrial volume index (LAVI). These associations were adjusted for a-priori selected confounders. Results Overall Z-scores for LGI or ED were not associated with echocardiographic measures. Effect modification by sex was apparent for ED with LVEF in both cohorts (P-for interaction = 0.08 and 0.06), but stratified results were not consistent. Effect modification by sex was apparent for TNF-α in the Hoorn Study and E-selectin in FLEMENGHO with LVEF (P-for interaction≤0.05). In the Hoorn Study, women whose TNF-α levels increased with 1-SD over time had a decrease in LVEF of 2.2 (-4.5;0.01) %. In FLEMENGHO, men whose E-selectin levels increased with 1-SD over time had a decrease in LVEF of 1.6 (-2.7;-0.5) %. Conclusion Our study did not show consistent associations of LGI and ED with echocardiographic measures. Some evidence of effect modification by sex was present for ED and specific biomarkers. |
Databáze: | OpenAIRE |
Externí odkaz: |