Persistent High-Risk HPV Infection and Molecular Changes Related to the Development of Cervical Cancer

Autor: Diana Mayorga, Oscar Gamboa, Nicolas Magné, Alfredo Romero-Rojas, Monica Molano, Alexis Vallard, Camila Casadiego, Nicolas Vial, Pablo Moreno-Acosta, Schyrly Carrillo, Antonio Huertas, Jinneth Acosta, Martha Cotes
Rok vydání: 2020
Předmět:
Zdroj: Case Reports in Obstetrics and Gynecology
Case Reports in Obstetrics and Gynecology, Vol 2020 (2020)
ISSN: 2090-6692
2090-6684
Popis: This article is a preliminary investigational study that is aimed at giving hints about the interesting biomarkers involved in the transition process from low-grade cervix lesion to invasive cervical cancer. Our study focuses on the risk factors and tumour molecular changes in one patient. First in 1986, she was diagnosed a preinvasive cervix lesion. Then, 16 years later, she was diagnosed an invasive cervical cancer. The 2002 diagnosis was a squamous cell carcinoma of the cervix, stage IIIB (FIGO), whereas in 1986, she had been diagnosed a high-grade squamous intraepithelial cervical lesion. Retrospectively, the analysis of samples of preneoplastic lesions and invasive cervical cancer confirmed the histopathological diagnoses and detected the presence of HPV type and HPV-16 variants, as well as the overexpression of proteins such as hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1. Finally, the Arg72Pro polymorphism was detected in TP53. The role of high-risk HPV and HPV-16 variants and of hTERT, IGF1Rα, IGF1Rβ, CAIX, and GLUT1 variations seemed confirmed in the development and progression of cervical cancer. As a result, analyzing the molecular changes in one and same tumour that progresses from a low-grade cervix lesion to invasive cervical cancer could provide valuable information in order to improve detection, diagnosis, and treatment in the future.
Databáze: OpenAIRE
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