Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade
| Autor: | Pierre Giglio, Milad Yazdani, Paul S. Morgan, Zoran Rumboldt, Ali Tabesh, Maria Vittoria Spampinato, Chiara Schiarelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences Brain tumor Sensitivity and Specificity Apparent diffusion coefficient Glioma Grading Magnetic resonance imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Parenchyma Preoperative Care medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Grading (tumors) Aged Aged 80 and over medicine.diagnostic_test business.industry Brain Neoplasms BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti Middle Aged medicine.disease Diffusion Magnetic Resonance Imaging Treatment strategy Female Nuclear medicine business Infiltration (medical) 030217 neurology & neurosurgery |
| Zdroj: | Clinical Imaging Volume 52 |
| ISSN: | 0899-7071 |
| DOI: | 10.1016/j.clinimag.2018.07.005 |
| Popis: | Preoperative identification of high-grade gliomas is critical to optimize treatment strategy and to predict prognosis. To determine whether perilesional apparent diffusion coefficient (ADC) values differ between high- and low-grade tumors, we assessed water diffusivity within normal-appearing brain parenchyma (NABP) surrounding gliomas in twenty-one treatment-naive patients. This showed significantly lower mean and 25th percentile (Q1) ADC values in high- grade compared to low-grade gliomas respectively in the range of 10–25 and 10–30 mm away from combined tumor and surrounding T2 signal. Thus, perilesional ADC measurement may reflect the extent of tumor infiltration beyond the abnormality seen on conventional MRI. |
| Databáze: | OpenAIRE |
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