In VivoandIn VitroExposures of Carp and Carp Tissues to Graded Concentrations of Endocrine Disrupting Chemicals
| Autor: | M Monteverde, Luigi Viganò, S. Bottero, R Bertolotti, F Pedemonte, Alberta Mandich, A. Massari, Alessandra Cevasco |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Carps Endocrine Disruptors Biology General Biochemistry Genetics and Molecular Biology Flutamide chemistry.chemical_compound Ovarian Follicle History and Philosophy of Science In vivo Internal medicine Testis Follicular phase medicine Animals Endocrine system Gonadal Steroid Hormones Carp Reproduction General Neuroscience biology.organism_classification In vitro Endocrinology chemistry Sex steroid Biomarker (medicine) Female lipids (amino acids peptides and proteins) |
| Zdroj: | Annals of the New York Academy of Sciences. 1040:234-238 |
| ISSN: | 0077-8923 |
| DOI: | 10.1196/annals.1327.032 |
| Popis: | The objective of this study was to correlate morphological and biochemical parameters of reproductive activity in fish exposed to graded concentrations of endocrine disrupting chemicals. Two-year-old carps were exposed for two weeks to graded concentrations of ethynyl-estradiol, tamoxifen, and flutamide. For each chemical, morphological alterations of the gonads and liver were described according to biomarker and sex steroid levels. In parallel, isolated follicular cells (FCs) and testis fragments were incubated in the presence or absence of carp pituitary homogenate and 25-hydroxycholesterol. Media were analyzed for sex steroid level evaluations. |
| Databáze: | OpenAIRE |
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