Women with a positive high-risk human papillomavirus (HPV) test remain at increased risk of HPV infection and cervical precancer ≥15 years later

Autor: Federica Inturrisi, Johannes A. Bogaards, Albert G. Siebers, Chris J.L.M. Meijer, Daniëlle A.M. Heideman, Johannes Berkhof
Přispěvatelé: Epidemiology and Data Science, AII - Infectious diseases, APH - Methodology, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Pathology
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Tumour Virus Research
Inturrisi, F, Bogaards, J A, Siebers, A G, Meijer, C J L M, Heideman, D A M & Berkhof, J 2022, ' Women with a positive high-risk human papillomavirus (HPV) test remain at increased risk of HPV infection and cervical precancer ≥15 years later ', Tumour virus research, vol. 14, 200240, pp. 200240 . https://doi.org/10.1016/j.tvr.2022.200240
Tumour virus research, 14:200240. Elsevier BV
ISSN: 2666-6790
DOI: 10.1016/j.tvr.2022.200240
Popis: Little is known about the long-term association between high-risk human papillomavirus (hrHPV) test results in women participating in a hrHPV-based cervical cancer screening program. To address this question, we collected data of 2217 women who participated in the POBASCAM hrHPV-based screening trial (enrolment 1999/2002) and also attended the Dutch hrHPV-based screening program between January 2017 and March 2018. Among 143 women who tested hrHPV-positive in 1999/2002, 45 (31.5%) had ≥ CIN2 or hysterectomy before 2017 and 17 (11.9%) tested hrHPV-positive at the 2017/2018 screen. In comparison, among 2074 women who tested hrHPV-negative in 1999/2002, 10 (0.5%) had ≥ CIN2 or hysterectomy before 2017 and 119 (5.7%) tested hrHPV-positive at the 2017/2018 screen. It follows that in the group of women who were not treated for ≥ CIN2 or had a hysterectomy in between the two screens 15 years apart (N = 2162), women who were hrHPV-positive in 1999/2002 had a higher risk of being hrHPV-positive in 2017/2018 than those who were hrHPV-negative in 1999/2002 (OR 3.4, 95% CI 1.8-6.1). A similar association was found at the genotype level for genotype-concordant results (5.1, 1.0-11.3) and for genotype non-concordant results (3.7, 1.6-6.7). Women who were hrHPV-positive in 2017/2018 had a higher risk of CIN3 after a hrHPV-positive result in 1999/2002 than after a hrHPV-negative result (5.8, 1.0-27.8). In conclusion, a positive hrHPV result in screening gives a long-term increased risk of a hrHPV-positive result, also for different genotypes, and a long-term increased risk of CIN3. This supports the concept of risk-stratification in hrHPV-based cervical cancer screening where previous hrHPV results are included in screening recommendations.
Databáze: OpenAIRE
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