Genetic polymorphisms influence on the response to clopidogrel in peripheral artery disease patients following percutaneous transluminal angioplasty
| Autor: | Xando Díaz-Villamarín, María Jesús Álvarez Cubero, José Cabeza Barrera, Fidel Fernández-Quesada, Cristina Lucía Dávila-Fajardo, Pedro Carmona-Sáez, Jesús Sánchez-Ramos, Luis Miguel Salmerón-Febres, Luis Javier Martinez-Gonzalez |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Ticlopidine Percutaneous Genotype Disease CYP2C19 030204 cardiovascular system & hematology Peripheral Arterial Disease 03 medical and health sciences 0302 clinical medicine Restenosis Internal medicine Occlusion Genetics Clinical endpoint Humans Medicine 030212 general & internal medicine Aged Pharmacology Polymorphism Genetic business.industry Angioplasty Graft Occlusion Vascular Atherosclerosis medicine.disease Clopidogrel Cytochrome P-450 CYP2C19 Treatment Outcome Lower Extremity Spain Cardiology Molecular Medicine Female business Platelet Aggregation Inhibitors Pharmacogenetics medicine.drug |
| Zdroj: | Pharmacogenomics. 17:1327-1338 |
| ISSN: | 1744-8042 1462-2416 |
| DOI: | 10.2217/pgs-2016-0056 |
| Popis: | Aim: To study the association of ABCB1 and CYP2C19 polymorphisms and the clopidogrel response in Spanish peripheral artery disease patients following percutaneous transluminal angioplasty (PTA) and to perform a meta-analysis. Materials & methods: 72 patients were recruited and 122 patients included in the meta-analysis. We evaluated the effect of ABCB1 3435 C>T, CYP2C19*2 and CYP2C19*3 and primary end point (restenosis/occlusion of the treated lesions) during 12 months after PTA. Results: CYP2C19*2 and/or ABCB1 TT patients were associated with primary end point (OR: 5.00; 95% CI: 1.75–14.27). The meta-analysis confirmed the association of CYP2C19*2 and new atherothrombotic ischemic events (OR: 5.40; 95% CI: 2.30–12.70). Conclusion: The CYP2C19 and ABCB1 polymorphisms could be genetic markers of cardiovascular events in peripheral artery disease patients following PTA treated with clopidogrel. |
| Databáze: | OpenAIRE |
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