Topological encoded vector beams for monitoring amyloid - lipid interactions in microcavity
| Autor: | Yu-Cheng Chen, Chaoyang Gong, Wenjie Wang, Pin Chieh Wu, Shih Hsiu Huang, Zhiyi Yuan, Zhen Qiao |
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| Přispěvatelé: | School of Electrical and Electronic Engineering, School of Chemical and Biomedical Engineering |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Amyloid
Optics and Photonics Materials science General Chemical Engineering Science General Physics and Astronomy Medicine (miscellaneous) Physics::Optics 02 engineering and technology Biosensing Techniques 010402 general chemistry Topology 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) Signal law.invention topological structures liquid crystals Liquid crystal law Biomimetics Amyloid-Lipid Interaction Nanotechnology General Materials Science laser modes Topology (chemistry) Research Articles vector beams business.industry Laser Modes General Engineering Chemical engineering [Engineering] amyloid‐lipid interaction Equipment Design 021001 nanoscience & nanotechnology Polarization (waves) Laser Lipids 0104 chemical sciences microcavity Electrical and electronic engineering [Engineering] Photonics 0210 nano-technology business Biosensor Lasing threshold Research Article |
| Zdroj: | Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021) Advanced Science |
| Popis: | Lasers are the pillars of modern photonics and sensing. Recent advances in microlasers have demonstrated its extraordinary lasing characteristics suitable for biosensing. However, most lasers utilized lasing spectrum as a detection signal, which can hardly detect or characterize nanoscale structural changes in microcavity. Here the concept of amplified structured light‐molecule interactions is introduced to monitor tiny bio‐structural changes in a microcavity. Biomimetic liquid crystal droplets with self‐assembled lipid monolayers are sandwiched in a Fabry–Pérot cavity, where subtle protein‐lipid membrane interactions trigger the topological transformation of output vector beams. By exploiting Amyloid β (Aβ)‐lipid membrane interactions as a proof‐of‐concept, it is demonstrated that vector laser beams can be viewed as a topology of complex laser modes and polarization states. The concept of topological‐encoded laser barcodes is therefore developed to reveal dynamic changes of laser modes and Aβ‐lipid interactions with different Aβ assembly structures. The findings demonstrate that the topology of vector beams represents significant features of intracavity nano‐structural dynamics resulted from structured light‐molecule interactions. The potential of vector laser beams is demonstrated to detect tiny bio‐structural changes in a microcavity through structured light‐molecule interactions. The topology of laser modes is converted into laser barcodes to reveal dynamic changes of amyloid‐lipid membrane interactions. Kinetic fingerprints of laser barcodes thus offer the potential for studying biophysical interactions in a wide range of biomedical applications. |
| Databáze: | OpenAIRE |
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