THOC5: a novel gene involved in HDL-cholesterol metabolism

Autor:	Moritz Koriath, Nigel W. Rayner, Maria Keller, Jana Breitfeld, Knut Krohn, Anke Tönjes, I Müller, B. Enigk, Julia Förster, Jan Halbritter, Leif Groop, Peter Kovacs, Andreas Pfeiffer, Antje Fischer-Rosinsky, Kerstin Weidle, Yvonne Böttcher, Ralph Burkhardt, Joachim Spranger, Michael Stumvoll, Dorit Schleinitz
Rok vydání:	2013
Předmět:	Adult Male Adolescent Population Single-nucleotide polymorphism Genome-wide association study QD415-436 ABCG8 Biology genome-wide-association study Polymorphism Single Nucleotide Biochemistry Cohort Studies Young Adult chemistry.chemical_compound Endocrinology Meta-Analysis as Topic single nucleotide polymorphism Germany mRNA silencing Humans Gene silencing RNA Messenger education Gene Aged Aged 80 and over Genetics education.field_of_study Triglyceride Cholesterol HDL Nuclear Proteins Hep G2 Cells Cell Biology Middle Aged SCARB1 chemistry Female lipids (amino acids peptides and proteins) Patient-Oriented and Epidemiological Research Genome-Wide Association Study
Zdroj:	Journal of Lipid Research, Vol 54, Iss 11, Pp 3170-3176 (2013)
ISSN:	0022-2275
Popis:	Although numerous genes are known to regulate serum lipid traits, identified variants explain only a small proportion of the expected heritability. We intended to identify further genetic variants associated with lipid phenotypes in a self-contained population of Sorbs in Germany. We performed a genome-wide association study (GWAS) on LDL-cholesterol, HDL-cholesterol (HDL-C), and triglyceride (TG) levels in 839 Sorbs. All single-nucleotide polymorphisms with a P value
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9734f13bc8f68a5e4746535289b20de https://doi.org/10.1194/jlr.m039420 Zobrazit plný text záznamu