Complementarities and network interactions in AIDS
| Autor: | Caner Süsal, Michael Grant, Volker Daniel, Geoffrey W. Hoffman, Gerhard Opelz |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Acquired Immunodeficiency Syndrome HLA-D Antigens biology CD8 Antigens Immunology Group ii Histocompatibility Antigens Class I Computational biology HIV Envelope Protein gp120 medicine.disease Major histocompatibility complex medicine.disease_cause Autoimmunity Autoimmune Diseases Immunoglobulin Fab Fragments Acquired immunodeficiency syndrome (AIDS) CD4 Antigens medicine biology.protein Immunology and Allergy Humans |
| Zdroj: | Journal of autoimmunity. 6(5) |
| ISSN: | 0896-8411 |
| Popis: | The contribution of autoimmune phenomena to the development of AIDS is not fully understood. In this paper we provide new evidence that idiotypic network interactions are operative in the development of AIDS. We furthermore present a model that involves two groups of antibodies and other molecules that are related to each other by a network of specific complementarities. We define Group I molecules to include antibodies and other molecules that have direct or indirect similarities with class I MHC molecules, and Group II substances that have similarities with class II MHC. We observe an inverse relationship between Group I antibodies (including anti-Fab) and Group II antibodies (including anti-anti-gp120, anti-anti-CD8 and anti-rCD4). The potential roles of members of these two groups in AIDS pathogenesis and/or protection are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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