The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut
| Autor: | Detlef Neumann, Bastian Schirmer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Carcinogenesis
Gastrointestinal Diseases colitis QH301-705.5 Inflammation Review Catalysis Allergic inflammation Inorganic Chemistry chemistry.chemical_compound Histamine receptor medicine Leukocytes Animals Humans cancer Histamine H4 receptor Physical and Theoretical Chemistry Colitis Biology (General) Molecular Biology QD1-999 Spectroscopy Receptors Histamine H4 business.industry epithelial cell Organic Chemistry General Medicine medicine.disease Mast cell Computer Science Applications Chemistry medicine.anatomical_structure chemistry inflammation Rheumatoid arthritis Immunology gut medicine.symptom business mast cell Histamine |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 6116, p 6116 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. Compounds acting on three out of the four known histamine receptors are approved for clinical use. These approved compounds comprise histamine H1-receptor (H1R) antagonists, which are used to control allergic inflammation, antagonists at H2R, which therapeutically decrease gastric acid release, and an antagonist at H3R, which is indicated to treat narcolepsy. Ligands at H4R are still being tested pre-clinically and in clinical trials of inflammatory diseases, including rheumatoid arthritis, asthma, dermatitis, and psoriasis. These trials, however, documented only moderate beneficial effects of H4R ligands so far. Nevertheless, pre-clinically, H4R still is subject of ongoing research, analyzing various inflammatory, allergic, and autoimmune diseases. During inflammatory reactions in gut tissues, histamine concentrations rise in affected areas, indicating its possible biological effect. Indeed, in histamine-deficient mice experimentally induced inflammation of the gut is reduced in comparison to that in histamine-competent mice. However, antagonists at H1R, H2R, and H3R do not provide an effect on inflammation, supporting the idea that H4R is responsible for the histamine effects. In the present review, we discuss the involvement of histamine and H4R in inflammatory and inflammation-associated diseases of the gut. |
| Databáze: | OpenAIRE |
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