Exercise as a therapeutic intervention for motor and non-motor symptoms in Parkinson’s disease: Evidence from rodent models
| Autor: | Erin K. Crowley, Yvonne M. Nolan, Aideen M. Sullivan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Parkinson's disease Nigrostriatal pathway Rodentia Disease Motor Activity 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Parkinsonian Disorders medicine Animals Humans Aerobic exercise business.industry General Neuroscience Dopaminergic medicine.disease Symptomatic relief Exercise Therapy Clinical trial 030104 developmental biology medicine.anatomical_structure Non motor business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Progress in Neurobiology. 172:2-22 |
| ISSN: | 0301-0082 |
| DOI: | 10.1016/j.pneurobio.2018.11.003 |
| Popis: | Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons of the nigrostriatal pathway, which leads to the cardinal motor symptoms of the disease - tremor, rigidity and postural instability. A number of non-motor symptoms are also associated with PD, including cognitive impairment, mood disturbances and dysfunction of gastrointestinal and autonomic systems. Current therapies provide symptomatic relief but do not halt the disease process, so there is an urgent need for preventative strategies. Lifestyle interventions such as aerobic exercise have shown potential to lower the risk of developing PD and to alleviate both motor and non-motor symptoms. However, there is a lack of large-scale randomised clinical trials that have employed exercise in PD patients. This review will focus on the evidence from studies on rodent models of PD, for employing exercise as an intervention for both motor and non-motor symptoms. |
| Databáze: | OpenAIRE |
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