Scaffold-based bone tissue engineering in microgravity: potential, concerns and implications
| Autor: | Federico Mochi, Elisa Scatena, Daniel Rodriguez, Maria-Pau Ginebra, Costantino Del Gaudio |
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| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya. BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits, Institut de Bioenginyeria de Catalunya, E. Amaldi Foundation |
| Rok vydání: | 2022 |
| Předmět: |
Ambients de microgravetat
Physics and Astronomy (miscellaneous) Enginyeria de teixits Space and Planetary Science Materials Science (miscellaneous) Medicine (miscellaneous) Enginyeria biomèdica::Enginyeria de teixits [Àrees temàtiques de la UPC] Tissue engineering Reduced gravity environments Agricultural and Biological Sciences (miscellaneous) Biochemistry Genetics and Molecular Biology (miscellaneous) |
| Zdroj: | NPJ microgravity. 8(1) |
| ISSN: | 2373-8065 |
| Popis: | One of humanity’s greatest challenges is space exploration, which requires an in-depth analysis of the data continuously collected as a necessary input to fill technological gaps and move forward in several research sectors. Focusing on space crew healthcare, a critical issue to be addressed is tissue regeneration in extreme conditions. In general, it represents one of the hottest and most compelling goals of the scientific community and the development of suitable therapeutic strategies for the space environment is an urgent need for the safe planning of future long-term manned space missions. Osteopenia is a commonly diagnosed disease in astronauts due to the physiological adaptation to altered gravity conditions. In order to find specific solutions to bone damage in a reduced gravity environment, bone tissue engineering is gaining a growing interest. With the aim to critically investigate this topic, the here presented review reports and discusses bone tissue engineering scenarios in microgravity, from scaffolding to bioreactors. The literature analysis allowed to underline several key points, such as the need for (i) biomimetic composite scaffolds to better mimic the natural microarchitecture of bone tissue, (ii) uniform simulated microgravity levels for standardized experimental protocols to expose biological materials to the same testing conditions, and (iii) improved access to real microgravity for scientific research projects, supported by the so-called democratization of space. |
| Databáze: | OpenAIRE |
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