Postreactivation mifepristone impairs generalization of strongly conditioned contextual fear memories
| Autor: | Charlotte R. Flavell, Rebecca M. Gascoyne, Jonathan L.C. Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cognitive Neuroscience Context (language use) Brief Communication Generalization Psychological Extinction Psychological Nootropic 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Memory Generalization (learning) Conditioning Psychological medicine Animals Freezing Reaction Cataleptic Nootropic Agents Cued speech Context effect Fear Pyrrolidinones Rats Mifepristone Neuropsychology and Physiological Psychology Nefiracetam Facilitation Memory consolidation Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Learn Mem |
| ISSN: | 1549-5485 |
| DOI: | 10.1101/lm.052167.120 |
| Popis: | The efficacy of pharmacological disruption of fear memory reconsolidation depends on several factors, including memory strength and age. We built on previous observations that systemic treatment with the nootropic nefiracetam potentiates cued fear memory destabilization to facilitate mifepristone-induced reconsolidation impairment. Here, we applied nefiratecam and mifepristone to strongly conditioned, 1-wk-old contextual fear memories in male rats. Unexpectedly, the combined treatment did not result in impairment of contextual fear expression. However, mifepristone did reduce freezing to a novel context. These observations suggest that strong and established contextual fear memories do undergo destabilization without the need for pharmacological facilitation, and that impairments in strong context fear memory reconsolidation can manifest as a reduction in generalization. |
| Databáze: | OpenAIRE |
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