Immunohistochemical study of tumour angiogenesis in oral squamous cell carcinoma
| Autor: | M. Moriyama, Shuichi Kawashiri, Etsuhide Yamamoto, Kiyoshi Kojima, K. Kakihara, Shigehiro Kumagai |
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| Rok vydání: | 1997 |
| Předmět: |
Vascular Endothelial Growth Factor A
Cancer Research Pathology medicine.medical_specialty Endothelium Angiogenesis Endothelial Growth Factors Neovascularization chemistry.chemical_compound medicine Carcinoma Humans Neoplasm Invasiveness Receptors Growth Factor Lymphokines Neovascularization Pathologic Vascular Endothelial Growth Factors business.industry Receptor Protein-Tyrosine Kinases medicine.disease Vascular endothelial growth factor stomatognathic diseases Vascular endothelial growth factor A Receptors Vascular Endothelial Growth Factor medicine.anatomical_structure Oncology Epidermoid carcinoma chemistry Lymphatic Metastasis Carcinoma Squamous Cell cardiovascular system Mouth Neoplasms Oral Surgery medicine.symptom business circulatory and respiratory physiology Blood vessel |
| Zdroj: | Oral Oncology. 33:369-374 |
| ISSN: | 1368-8375 |
| DOI: | 10.1016/s1368-8375(97)00025-0 |
| Popis: | To assess the clinical significance of angiogenesis in oral squamous cell carcinoma (SCC), we examined vessel density immunohistochemically in 44 primary oral SCCs using the JC-70A antibody which reacts specifically with vascular endothelial cells. In addition, the expression of vascular endothelial growth factor (VEGF) and its receptors, KDR, Flt-1 and Flt-4 in oral SCCs was examined in relation to the vessel density and lymph node metastasis. There was no association of vessel density with tumour site, T-category (tumour size), degree of differentiation or cervical lymph node metastasis, except that the vessel density of carcinomas with a well-defined tumour-stromal boundary was higher than that of diffusely invasive carcinomas. The intensity of VEGF expression correlated with lymph node metastasis (P < 0.01), but not with vessel density. The expression of KDR and Flt-1 did not correlate with vessel density and lymph node metastasis. However, the vessel density in Flt-4-positive carcinomas was higher than that in Flt-4-negative carcinomas (P < 0.05), and expression of Flt-4 most significantly correlated with lymph node metastasis (P < 0.001). These results suggest that the expression of VEGF or Flt-4 rather than vessel density may be a predictor of lymph node metastasis in oral SCC. |
| Databáze: | OpenAIRE |
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