Analysis of allelic variation of the TAP2 gene in sarcoidosis
| Autor: | Mami Ishihara, Etsuko Maruya, Hidetoshi Inoko, Taeko Naruse, M. Kagiya, Shigeaki Ohno, Takako Ishida, Nobuhisa Mizuki, Hiroo Saji |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Sarcoidosis Immunology Biology Major histocompatibility complex Biochemistry Major Histocompatibility Complex ATP Binding Cassette Transporter Subfamily B Member 3 Genetic variation Genetics Genetic predisposition medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Gene Alleles HLA-D Antigens Genetic Variation General Medicine medicine.disease biology.protein TAP2 ATP-Binding Cassette Transporters Female |
| Zdroj: | Tissue Antigens. 49:107-110 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | Sarcoidosis is a systemic granulomatous disease and the DRB1 gene of the DR subregion has been implicated for determining the genetic susceptibility to the disease. We evaluated the allelic variation of the TAP2 gene using the PCR-RFLP method as well as the mismatched PCR-RFLP method in 82 Japanese patients with sarcoidosis and 92 healthy controls. A new allele, TAP2*0103 and a new polymorphic variation at codon 577 in addition to TAP2*0101, TAP2*0102 and TAP2*0201 have been recognized in the Japanese subjects. No significant differences were observed in the frequencies of any TAP2 alleles or dimorphism at codon 577 between the patients and healthy controls. Polymorphic variation of the TAP2 gene does not confer the susceptibility to sarcoidosis. |
| Databáze: | OpenAIRE |
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