Does gestational diabetes history increase epicardial fat and carotid intima media thickness?

Autor:	Cevdet Duran, Harun Koca, Ozge Telci Caklili, Mustafa Kulaksizoglu, Haldun Muderrisoglu, Faika C. Çiftçi, Enver Avci, Mustafa Caliskan, Zuhal Caliskan, Hakan Gullu
Rok vydání:	2014
Předmět:	Adult medicine.medical_specialty endocrine system diseases Population Type 2 diabetes Carotid Intima-Media Thickness Risk Assessment Severity of Illness Index chemistry.chemical_compound Young Adult Insulin resistance Predictive Value of Tests Pregnancy Reference Values Internal medicine medicine Humans Radiology Nuclear Medicine and imaging education education.field_of_study business.industry Surrogate endpoint Incidence nutritional and metabolic diseases Middle Aged medicine.disease Atherosclerosis Prognosis Gestational diabetes Diabetes Gestational Endocrinology chemistry Intima-media thickness Adipose Tissue Echocardiography Case-Control Studies Multivariate Analysis Cardiology Linear Models Uric acid Female Cardiology and Cardiovascular Medicine business Pericardium
Zdroj:	Echocardiography (Mount Kisco, N.Y.). 31(10)
ISSN:	1540-8175
Popis:	Background Gestational diabetes mellitus (GDM) is defined as glucose intolerance that has begun during pregnancy. Recent studies have proven that development of atherosclerosis may be established in this population even without presence of type 2 diabetes. For assessment of atherosclerosis, epicardial fat thickness (EFT) is recently being used as a surrogate marker. In this study, we aimed to prove that women with GDM history are more inclined to have higher EFT levels than women without GDM history. Methods Sixty-two patients with previous GDM and 33 age- and sex-matched controls were allocated. Epicardial fat thicknesses of the subjects were measured with transthorasic echocardiography and carotid intima media thickness (c-IMT) was measured with ultrasound. Insulin resistance (IR) of each subject was assessed with Homeostasis model of assessment—insulin resistance (HOMA-IR). Results Carotid IMT and EFT were significantly higher in previous GDM group than controls. Serum gamma-glutamyl transferase (GGT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) levels were also found significantly higher in the patients with previous GDM as compared to the controls. We observed that carotid IMT (β = 310, P = 0.003), total cholesterol (β = 315, P = 0.002), BMI (β = 308, P = 0.002), HbA1c (β = 227, P = 0.018), and HOMA-IR (β = 184, P = 0.049) were independently correlated with EFT. Conclusions Although the number of patients included in this study is limited, high EFT results may indicate presence of atherosclerosis in women with previous GDM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96b90782675483f88c379e1fefaa52f https://pubmed.ncbi.nlm.nih.gov/24666015 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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