Prognostic factors and nomogram for cancer-specific death in non small cell lung cancer with malignant pericardial effusion
| Autor: | Fan Jun Zeng, Zhigang Hu, Ke Hu, Wen Xin Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Oncology Lung Neoplasms Cancer Treatment Kaplan-Meier Estimate Pericardial effusion Lung and Intrathoracic Tumors Metastasis Small Cell Lung Cancer 0302 clinical medicine Carcinoma Non-Small-Cell Lung Cause of Death Cardiac tamponade Basic Cancer Research Medicine and Health Sciences Cause of death education.field_of_study Multidisciplinary Pharmaceutics Middle Aged Prognosis Survival Rate Treatment Outcome 030220 oncology & carcinogenesis Calibration Medicine Female Anatomy Research Article Clinical Oncology medicine.medical_specialty Science Population Pericardial Effusion Lymphatic System Cancer Chemotherapy 03 medical and health sciences Drug Therapy Diagnostic Medicine Internal medicine medicine Chemotherapy Humans Propensity Score education Lung cancer Survival rate Aged Proportional Hazards Models business.industry Proportional hazards model Cancers and Neoplasms Biology and Life Sciences Nomogram medicine.disease United States Non-Small Cell Lung Cancer Cardiac Tamponade Nomograms 030104 developmental biology Lymph Nodes Clinical Medicine business SEER Program |
| Zdroj: | PLoS ONE, Vol 14, Iss 5, p e0217007 (2019) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0217007 |
| Popis: | BackgroundThe prognosis of lung cancer with malignant pericardial effusion is very terrible owing to the impact of cardiac tamponade. The aim of our study seeks to identify prognostic factors and establish a prognostic nomogram of non small cell lung cancer (NSCLC) with malignant pericardial effusion.MethodsNSCLC patients with malignant pericardial effusion between 2010 and 2014 are searched from SEER database.Cancer-specific death of these patients are analyzed through the Kaplan-Meier method, Cox proportional hazard model and competing risk model. Prognostic nomogram of cancer-specific death is performed and validated with concordance index (C-index), calibration plots and internal validation population. Propensity score matching is used to evaluate whether chemotherapy affected the survival of study population.Results696 eligible NSCLC patients are involved in the study population, with 22.7% of 1-year survival rate and 8.9% of 2-year survival rate. Laterality, AJCC N, AJCC T, and chemotherapy are regarded as independent prognostic factors of cancer-specific death in the Cox proportional hazards model and competing risk model. The C-index of established nomogram is 0.703(95%CI:0.68-0.73) for cancer-specific death in the study population with acceptable calibration, which is significantly higher than classical TNM stage(C-index = 0.56, 95%CI:0.52-0.60). After 1:1 propensity score matching, chemotherapy potentially reduces the risk of cancer-specific death (HR = 0.42 95%CI: 0.31-0.58) of NSCLC with pericardial effusion.ConclusionsNSCLC with malignant pericardial effusion harbors low overall survival. One prognostic nomogram based on laterality, AJCC N, AJCC T and chemotherapy is developed for cancer-specific death to predict 1-year and 2-year survival rate with good performance. |
| Databáze: | OpenAIRE |
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