Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro
| Autor: | Qin Huang, Ning Huang, Xiang Zhang, Yuan Cheng, Guanjian Zhao, Ying Tan, Peng Zhang, Menghuan Tang |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biophysics Nanoparticle Antineoplastic Agents Apoptosis Conjugated system Biochemistry 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Glioma Autophagy Temozolomide medicine Animals Molecular Biology Drug Carriers Chemistry Adenine Cell Biology Mesoporous silica Silicon Dioxide medicine.disease In vitro Rats 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Nanoparticles Oligopeptides medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 509:549-556 |
| ISSN: | 0006-291X |
| Popis: | Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. Anticancer drugs can cause autophagy in tumor cells, whereas autophagy inhibitors can block this reaction and enhance the therapeutic effect of the drugs. In this study, we demonstrated that MSNP-TMZ-PDA-NGR had stronger autophagy- and apoptosis-inducing effects in C6 cells than TMZ alone, and its anticancer effect was further enhanced when combined with autophagy inhibition. These results demonstrate that the combination of targeting vehicles and autophagy inhibitors may have research value in the treatment of gliomas. |
| Databáze: | OpenAIRE |
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