Acute changes in forearm venous volume and tone using radionuclide plethysmography
| Autor: | Eldon R. Smith, V. J. B. Robinson, Dante E. Manyari, K. E. Cooper, T. J. Malkinson |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.diagnostic_test
Physiology business.industry Technetium Scintigraphy Muscle Smooth Vascular Veins Plethysmography Forearm Blood pressure medicine.anatomical_structure Nifedipine Physiology (medical) Cardiovascular agent Heart rate Humans Plethysmograph Medicine Cardiology and Cardiovascular Medicine business Vein Nuclear medicine medicine.drug |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 255:H947-H952 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.1988.255.4.h947 |
| Popis: | In this investigation blood pool scintigraphy was validated as a method to study acute changes in human forearm veins. Changes in regional forearm vascular volume (capacity) and the occluding pressure-volume (P-V) relationship induced by sublingual nifedipine (NIF) and nitroglycerin (GTN) were recorded in 16 patients with simultaneous data collection by the radionuclide and the mercury-in-rubber strain-gauge techniques. The standard error of estimate (Syx) between successive control measurements using the radionuclide method was 3.1% compared with 3.2% for the strain-gauge method. The venous P-V curves were highly reproducible using both techniques. Strain gauge and radionuclide measurements of acute changes in forearm venous volume correlated well (r = 0.86; Syx = 7%, n = 156). After 20 mg of NIF or 0.6 mg of GTN, mean heart rate increased from 71 +/- 10 to 77 +/- 9 and from 68 +/- 10 to 75 +/- 11 beats/min, respectively, and group systolic blood pressure decreased from 128 +/- 22 to 120 +/- 19 and from 136 +/- 18 to 126 +/- 23 mmHg, respectively (P less than 0.05). At venous occluding pressures of 0 and 30 mmHg, the forearm vascular volume did not change after NIF (2 +/- 4 and -1 +/- 4%; P greater than 0.05), whereas it increased after GTN (8 +/- 5 and 12 +/- 7%; P less than 0.001). The forearm venous P-V relationship did not change after NIF, whereas a significant rightward shift (venodilation, with an increase in unstressed volume) occurred after GTN.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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